PE-22-28 10mg

PE-22-28 10 mg

Buy PE-22-28 10 mg for laboratory research, supplied as lyophilized powder in one boxed 3 mL vial.

PE-22-28 is a shortened, seven-residue spadin-related peptide studied as an inhibitor of the TREK-1 potassium channel.

Match the peptide to your method

PE-22-28, full-length spadin and terminally modified PE-22-28 analogs are distinct research materials. Match the sequence and terminal chemistry used in your reference method before selecting specifications or making preparation calculations.

The original shortened-spadin study compared the parent sequence with peptides carrying end-group changes or an amino-acid substitution. Some modifications retained channel inhibition; others did not. A shared name fragment therefore does not establish equivalent activity.

The 10 mg amount is the package label, not an assay concentration. The 3 mL figure describes vial capacity; the supplied material is powder, not 3 mL of prepared solution.

TREK-1 research context

In the same 2017 study, researchers used whole-cell patch-clamp recordings in HEK cells expressing human TREK-1. They measured changes in channel current and compared PE-22-28 with spadin and modified analogs. Testing against several other potassium channels helped assess specificity under those experimental conditions.

The work also measured behavior in mice, including immobility in the forced swim test and feeding latency in another test. These endpoints address different questions from channel-current measurements. They do not establish a clinical outcome or demonstrate how this commercial preparation will perform in a different assay.

Product documents and analytical checks

Open Documents to review the files currently available for this item. Where a batch report is available, match its product identity and lot before using its results. A general product file and a lot-specific analytical report serve different purposes.

Review identity, chromatographic purity and measured content as separate properties. For chemical calculations, confirm the supplied form rather than borrowing an acetate or other salt specification from another supplier. Storage and prepared-solution conditions should likewise follow evidence for the actual material and the requirements of your laboratory method.