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ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are intended solely for research and laboratory use. These products are not intended for human or animal consumption. They are not medicines or drugs and have not been evaluated or approved by the FDA to diagnose, treat, cure, or prevent any disease or medical condition. Any form of bodily introduction is strictly prohibited by law.
PE-22-28 10mg is a research-use-only laboratory material supplied for controlled research workflows, compound characterization, and analytical documentation review. It is manufactured under rigorous quality standards to support consistency, traceability, and batch-specific verification for qualified laboratory settings.
PE-22-28 10mg is intended strictly for laboratory research use only. This product is not intended for human or animal consumption, therapeutic use, diagnostic use, clinical use, veterinary use, or as a food, drug, cosmetic, dietary supplement, or household product.
| CAS No. | 1801959-12-5 |
|---|---|
| Purity | ≥99% |
| Sequence | GVSWGLR |
| Molecular Formula | C35H55N11O9 |
| Molecular Weight | 773.89 g/mol |
| Applications | Depression models, neurogenesis studies, stroke recovery, TREK-1 inhibition |
| Synthesis | Solid-phase synthesis |
| Solubility | Soluble in water or 1% acetic acid |
| Stability & Storage | Stable for up to 24 months at -20°C. After reconstitution, may be stored at 4°C for up to 4 weeks or at -20°C for up to 6 months. |
| Appearance | White lyophilized powder |
| Shipping Conditions | Shipped at ambient temperature; once received, store at -20°C |
| Regulatory/Compliance | Manufactured in a facility that adheres to cGMP guidelines |
| Safety Information | Refer to provided MSDS |
Consider these supplementary peptides for a comprehensive research approach.
Researchers searching for buy PE-22-28 online should evaluate PE-22-28 as a research-use-only laboratory material, not a consumer product. For laboratory buyers, the key considerations are compound identity, PE-22-28 purity documentation, batch-specific COAs, lot traceability, product labeling, and storage information. This guide explains how to evaluate PE-22-28 for controlled research procurement through Pure Lab Peptides, with emphasis on documentation, identity testing, analytical support, and supplier transparency.
Researchers can buy PE-22-28 online for laboratory research by reviewing RUO labeling, batch-specific COA documentation, purity data, identity information, storage guidance, and supplier transparency before selecting a source. Products discussed in this article are intended for laboratory research use only and are not intended for human or animal consumption.
The phrase `buy PE-22-28 online` is addressed here as laboratory research procurement intent, not personal-use intent. In this context, the search is not about use outcomes, preparation methods, or personal decision-making. It is about whether a research-use-only supplier provides enough documentation for qualified researchers, laboratory buyers, research institutions, and technical procurement teams to make a controlled sourcing decision.
For PE-22-28, that review begins with identity. Public chemical records identify PE-22-28 as a short peptide with PubChem CID 165437303 and the molecular formula C35H55N11O9 [1]. Published spadin-analog research describes PE 22-28 as a seven-amino-acid sequence evaluated in TREK-1 channel models, which places it in a neuroactive peptide-derivative research category [2]. A procurement review should therefore focus on PE-22-28 supplier documentation, identity testing, purity data, lot-level traceability, and research-use-only labeling.
Commercial search language can be used responsibly when every buying reference is qualified. Researchers searching to buy PE-22-28 online for laboratory research should review the batch-specific COA, match the lot number across product labeling and documentation, confirm the stated product form, and evaluate whether supplier language avoids personal-use, clinical-use, or outcome-based claims.
PE-22-28 is a short synthetic peptide discussed in the literature as a shortened analog of spadin, a sortilin-derived peptide that was originally described in TREK-1 channel research [3]. Public compound data identify PE-22-28 by the synonym PE 22-28, molecular formula C35H55N11O9, and CID 165437303 [1]. The sequence reported in research literature is Gly-Val-Ser-Trp-Gly-Leu-Arg, commonly represented as GVSWGLR [2].
Research literature places PE-22-28 in a TREK-1 or K2P2.1 channel context. TREK-1 is encoded by KCNK2 and is listed by UniProt as potassium channel subfamily K member 2 [4]. The IUPHAR/BPS Guide to Pharmacology also maps K2P2.1/TREK-1 within the two-pore domain potassium channel family and summarizes key references for this target class [5]. For RUO procurement, these records are useful for category context only. They do not validate a specific supplier lot, establish product-use instructions, or replace a PE-22-28 COA.
As a neuroactive peptide derivative, PE-22-28 should be described with narrow, documentation-centered language. Researchers may discuss sequence, molecular identity, analytical characterization, and published channel-model context. Published research context should not be interpreted as cognitive, mood, or wellness guidance for RUO materials.
Researchers usually search this phrase because online procurement workflows need quick confirmation that a material exists in a documented RUO format. A qualified buyer may need to compare product name, fill size, peptide category, purity claim, product form, COA access, and supplier language before a purchase request can be routed through a laboratory or institutional process.
For PE-22-28 research material, the procurement question is not “what result does this produce?” The better question is “does the supplier provide enough documentation to support a controlled laboratory record?” That means reviewing the PE-22-28 COA, purity data, identity testing method, lot number, product form, storage and handling information, and whether the supplier avoids unsupported personal-use language.
Technical procurement teams that buy PE-22-28 should also evaluate whether the product page is consistent with the underlying literature. PE-22-28 is discussed in peptide and ion-channel research, including work on shortened spadin analogs [2]. That literature supports research context, not product-use claims.
Researchers comparing suppliers to buy PE-22-28 online for laboratory research should treat documentation as the central quality signal. Analytical procedure guidance from ICH and FDA emphasizes that identity, purity, and other quality attributes are supported by fit-for-purpose analytical procedures rather than by a single label statement alone [6] [7].
| Evaluation Area | What Researchers Should Review | Why It Matters for RUO Procurement |
| RUO labeling | Confirm the product is clearly labeled for research use only | Helps separate research procurement from human-use positioning |
| COA availability | Review the available batch-specific certificate of analysis | Supports lot-level documentation and quality review |
| Purity data | Look for analytical support for the stated purity | Helps evaluate material consistency |
| Identity testing | Review HPLC, LC-MS, mass spectrometry, or related identity data listed in documentation | Helps confirm the material matches the listed compound |
| Lot traceability | Match lot numbers across product and documentation | Supports research recordkeeping |
| Product form | Confirm whether the material is supplied as lyophilized powder or another documented form | Supports laboratory planning |
| Storage information | Review storage and handling documentation | Helps maintain material integrity in laboratory settings |
| Supplier language | Confirm the supplier avoids dosing, therapeutic, or personal-use claims | Supports research-use-only positioning |
A PE-22-28 COA should be reviewed as a batch-level document, not as a generic marketing claim. Researchers should look for the compound name, lot number, test date, purity percentage, analytical method, identity confirmation, molecular weight or formula when listed, sequence information when listed, chromatographic or mass data, product form, and storage documentation. The product label and COA should refer to the same material and the same lot.
A purity percentage alone does not establish complete compound identity; researchers should evaluate purity, identity, method, lot number, and documentation together. HPLC is commonly used to separate and quantify components in analytical workflows, while LC-MS and tandem mass spectrometry can support molecular identity and peptide-related characterization [8]. ICH Q14 describes science- and risk-based analytical procedure development, which is relevant when laboratories evaluate whether a method is suitable for its stated purpose [9].
Lot-level traceability also matters because a COA should correspond to the material under review. NIST definitions for reference materials describe certificates as documents that state property values and related traceability information for certified reference materials, illustrating why documentation is central to laboratory quality review [10]. PE-22-28 purity documentation should therefore be read together with identity testing and supplier records.
Published PE-22-28 literature is limited and should be read as scientific context, not product-use guidance. The main primary paper on shortened spadin analogs describes PE 22-28 as a seven-amino-acid peptide designed from spadin degradation-product research and evaluated in TREK-1 channel models [2]. A later review discusses spadin-analog strategies, including sequence shortening, within TREK-1 blocker research [11].
The broader target class is better developed than the direct PE-22-28 literature. Foundational K2P channel work describes two-pore domain potassium channels as background or leak potassium channels involved in membrane potential and excitability regulation [12]. Additional reviews describe the physiology and pharmacology of two-pore domain potassium channels and the diversity of K2P channel regulation [13] [14]. These sources help explain why TREK-1 appears in the research literature, but they do not establish any use instructions for PE-22-28 research-use-only material.
Several spadin-related studies report preclinical or model-system findings, including work on spadin, retro-inverso analogs, sortilin-derived peptides, and related channel or signaling endpoints [3] [15] [16] [17]. Those papers are useful for literature mapping and category context. They should not be converted into PE-22-28 product claims, procurement promises, or protocol guidance.
Additional target context can be drawn from early TREK-1 and K2P literature and database records. Fink and colleagues described a neuronal two-P-domain potassium channel stimulated by arachidonic acid and polyunsaturated fatty acids [18]. Reviews of K2P gating summarize structural and regulatory features of this channel family [19]. Human TREK-1 orthologue work, structural records for human TREK1/K2P2.1, and the NCBI KCNK2 gene record provide target-identification context for researchers mapping the literature [20] [21] [22].
Published research context should not be interpreted as cognitive, mood, or wellness guidance for RUO materials. Researchers should distinguish three separate questions: what the literature says about a peptide or target class, what a supplier documents for a specific lot, and what a laboratory is authorized to do under its internal research plan. This article addresses only the procurement and documentation question.
| Research Area | What Literature Examines | Evidence Type | RUO Interpretation |
| Compound identity | Molecular structure, sequence, formula, and classification | Database / analytical | Supports identification, not product-use claims |
| Pathway or category context | TREK-1/K2P2.1 channel research and spadin-analog literature | Review / in vitro / preclinical | Useful for research context, not therapeutic claims |
| Analytical testing | Purity, identity, and batch verification | HPLC / LC-MS / mass spectrometry / COA | Supports documentation review |
| Storage and stability | Material form and handling considerations | Laboratory documentation | Supports research workflow planning |
| Research-Safe Statement | Why It Is Acceptable | Non-Compliant Version to Avoid |
| “PE-22-28 is discussed in published research related to TREK-1/K2P channel models.” | Describes literature context without making a product claim | “PE-22-28 helps with a human outcome.” |
| “Researchers should review COA and identity data before procurement.” | Focuses on documentation and quality review | “Users should buy PE-22-28 for results.” |
| “Pure Lab Peptides supplies PE-22-28 as a research-use-only material.” | Clarifies intended use | “Pure Lab Peptides supplies PE-22-28 for therapy.” |
| “The phrase buy PE-22-28 online is addressed as research procurement intent.” | Qualifies commercial search intent | “Buy PE-22-28 online for personal use.” |
| “PE-22-28 identity testing should be reviewed together with purity documentation.” | Connects analytical review with procurement records | “A purity percentage proves everything needed about PE-22-28.” |
Pure Lab Peptides presents PE-22-28 10mg as a research-use-only laboratory material. The product is positioned for controlled laboratory research procurement, with a ≥99% purity claim, lyophilized powder form, and an available batch-specific COA. Researchers should review the product page and batch-specific documentation to confirm product details, identity information, PE-22-28 purity documentation, lot-level traceability, and storage and handling information.
Review the Pure Lab Peptides PE-22-28 research-use-only product page for RUO labeling, product details, purity information, and batch-specific documentation. Researchers comparing broader sourcing options can also review the research peptide collection, the Pure Lab Peptides blogs, and shipping and returns information for procurement planning.
Buy PE-22-28 online should not be interpreted as personal-use guidance on this page. The phrase is addressed as laboratory procurement intent for qualified researchers reviewing RUO labeling, documentation, purity data, identity information, lot traceability, and supplier transparency.
Published literature may describe PE-22-28, spadin analogs, TREK-1, or K2P channels in experimental settings. That context is not a protocol for RUO materials. Laboratory buyers should separate peer-reviewed research from supplier-lot documentation and from any internal research authorization.
PE-22-28 purity documentation is important, but purity percentage alone is not a complete identity review. Researchers should evaluate the compound name, lot number, method, sequence or molecular information, chromatographic data, mass data, and label consistency together before documenting procurement.
A generic specification sheet is not the same as a batch-specific COA. Research procurement teams should match the PE-22-28 COA to the lot received or selected. Lot-level traceability helps connect the research record to the exact material documented by the supplier.
RUO labeling separates laboratory research material from clinical, diagnostic, personal, or consumer positioning. FDA RUO guidance for IVD products emphasizes that RUO labeling must be consistent with intended use, and 21 CFR 809.10 describes RUO labeling language for products in the laboratory research phase of development [23] [24]. Although PE-22-28 is not being presented here as an IVD, the broader lesson is that labeling and intended use must align.
TREK-1 pathway relevance helps classify the literature, not the product. Researchers may cite KCNK2, K2P channel, or spadin-analog sources when describing context, but a supplier lot still requires COA review, identity testing, purity documentation, and research-use-only boundaries.
Researchers can buy PE-22-28 online for laboratory research from an RUO supplier that provides clear labeling, product documentation, purity information, and an available batch-specific COA. Pure Lab Peptides lists PE-22-28 10mg with research-use-only positioning, lyophilized powder form, and documentation for laboratory procurement review.
Before buying PE-22-28 online, researchers should check RUO labeling, PE-22-28 COA availability, purity documentation, identity testing, product form, lot-number consistency, storage information, and supplier language. The supplier should present PE-22-28 as a laboratory research material and avoid claims related to personal or clinical use.
A COA matters when buying PE-22-28 because it connects the selected or received lot to analytical documentation. A useful PE-22-28 COA should support review of compound name, lot number, purity, method, identity information, test date, and product consistency. It should be reviewed with the product label and research records.
PE-22-28 discussed on this page is not intended for human or animal consumption. It is addressed as a PE-22-28 research-use-only material for controlled laboratory procurement. Researchers should evaluate labeling and supplier documentation to confirm that the product is positioned for laboratory research only.
Research use only for PE-22-28 means the material is supplied for laboratory research workflows, documentation review, and controlled research procurement. It does not create clinical, diagnostic, veterinary, personal, or consumer-use authorization. Procurement teams should document RUO labeling, PE-22-28 supplier documentation, and batch-specific COA records.
Published literature about PE-22-28 should be interpreted as research context. Literature may describe peptide identity, spadin-analog design, TREK-1 channel models, or broader K2P channel biology. Those sources do not replace batch-specific documentation and should not be converted into product-use guidance for RUO materials.
For research teams comparing PE-22-28 suppliers, prioritize COA availability, transparent labeling, PE-22-28 identity testing, purity documentation, and lot-level traceability. Review the PE-22-28 product page for RUO labeling, product details, purity information, and available batch-specific documentation before selecting any research-use-only material.
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