LL-37 5 mg: research material

Buy LL-37 5 mg for laboratory research, supplied as lyophilized powder in one boxed 3 mL vial.

LL-37 is a 37-amino-acid human cathelicidin peptide studied in host defense, antimicrobial assays and membrane interactions. It is the mature peptide released from the larger hCAP-18 precursor.

Choose the material and presentation

This listing is for LL-37 research material, not the full hCAP-18 precursor. Mature peptide, precursor protein and modified fragments answer different experimental questions. Match the required sequence, terminal chemistry and any specified chemical form to the available product records.

The 5 mg amount and 3 mL vial capacity describe different properties: material mass and container volume. They do not specify a solution concentration. For method comparisons, retain the actual preparation and assay conditions rather than assuming that equal labeled mass produces equal activity.

What original LL-37 experiments show

Precursor processing in human neutrophil material

Sørensen and colleagues investigated how hCAP-18 is processed into LL-37. They detected cleavage in material released by exocytosis, but not detectable cleavage within cells after phagocytosis. Among the three granule serine proteases examined, proteinase 3 accounted for the extracellular processing.

This identifies a specific step in human precursor biology. It does not mean that a supplied mature LL-37 preparation needs to reproduce that processing step, or that its composition is verified by the paper.

Read the original processing study

Antimicrobial findings depend on assay conditions

Turner and colleagues compared LL-37 with other antimicrobial peptides using radial-diffusion and broth-microdilution assays. Some organisms were susceptible under both tested salt conditions; others, including the examined methicillin-resistant Staphylococcus aureus, Proteus mirabilis and Candida albicans, were susceptible in low-salt media but resistant when the media contained 100 mM NaCl.

The study also measured membrane permeabilization and lipopolysaccharide binding in defined bacterial systems. These findings make the organism, medium and endpoint essential parts of a research comparison. A general “antimicrobial” label is not a universal activity guarantee or evidence of clinical treatment performance.

Read the original activity study

Product records and batch reports

The product documentation section contains available batch reports and product files. Match the lot and identity information before comparing analytical results. A chromatographic purity result, an identity assignment and measured content answer different questions.

Use the relevant product records and laboratory method for handling and storage. Published biological activity does not certify a catalog lot or establish a storage period. Check assay-specific requirements separately from the purchase quantity.