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AICAR 50mg

$54.99

(5.0) (20 customer reviews)

Research Studies:

  • Potent AMPK agonist for investigating cellular energy homeostasis and metabolic flux signaling
  • Facilitates analysis of ZMP-mediated stimulation of glucose uptake and fatty acid oxidation
  • Supports research on PGC-1α-induced mitochondrial biogenesis and respiratory chain gene expression
  • Enables investigation of exercise-mimetic effects on skeletal muscle metabolic reprogramming in assays

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ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are intended solely for research and laboratory use. These products are not intended for human or animal consumption. They are not medicines or drugs and have not been evaluated or approved by the FDA to diagnose, treat, cure, or prevent any disease or medical condition. Any form of bodily introduction is strictly prohibited by law.

Description

AICAR 50mg is a research-use-only laboratory material supplied for controlled research workflows, compound characterization, and analytical documentation review. It is manufactured under rigorous quality standards to support consistency, traceability, and batch-specific verification for qualified laboratory settings.

Key Product Details

  • Manufactured in accordance with rigorous quality standards to support ≥99% purity, as reflected in batch-specific documentation where available.
  • Every batch is third-party analyzed for identity, assay/potency, and sterility documentation where applicable.
  • Supplied in lyophilized powder form to help preserve stability throughout transport and storage.
  • Produced with lot-level traceability to support research documentation and laboratory recordkeeping.

Research Documentation Context

  • Supports compound characterization in controlled laboratory settings.
  • Provides batch-specific identity and purity documentation for research review.
  • Allows lot-level traceability across laboratory documentation workflows.
  • Supports comparison of product labeling, analytical documentation, and storage information during research planning.
  • Supports analytical review of research compound materials within a strictly laboratory-focused context.

Specifications and Documentation

  • Certificate of Analysis: Available with batch-specific documentation where applicable.
  • Material Safety Data Sheet: Coming Soon.
  • Handling and Storage Instructions: Coming Soon.
  • Product Form: Lyophilized powder.
  • Purity Specification: ≥99% purity.
  • Intended Use: Laboratory research use only.

AICAR 50mg is intended strictly for laboratory research use only. This product is not intended for human or animal consumption, therapeutic use, diagnostic use, clinical use, veterinary use, or as a food, drug, cosmetic, dietary supplement, or household product.

Additional information

CAS No.

2627-69-2

Purity

≥99%

Sequence

N/A

Molecular Formula

C9H14N4O5

Molecular Weight

258.23 g/mol

Applications

AMPK activation research, metabolic function studies, endurance and exercise physiology models

Synthesis

Solid-phase synthesis

Format

Lyophilized powder

Solubility

Soluble in water or 1% acetic acid

Stability & Storage

Stable for up to 24 months at -20°C. After reconstitution, may be stored at 4°C for up to 4 weeks or at -20°C for up to 6 months.

Appearance

White lyophilized powder

Safety Information

Refer to provided MSDS

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Research Procurement Information

Buy AICAR Online for Laboratory Research | COA Guide

Researchers searching for buy AICAR online should evaluate AICAR as a research-use-only laboratory material, not a consumer product. For laboratory buyers, the key considerations are compound identity, purity documentation, batch-specific COAs, lot traceability, product labeling, and storage information. This guide explains how to evaluate AICAR for controlled research procurement through Pure Lab Peptides, with emphasis on RUO supplier evaluation and analytical documentation.

Fast Answer: buy AICAR online for laboratory research

Researchers can buy AICAR online for laboratory research by reviewing RUO labeling, batch-specific COA documentation, purity data, identity information, storage guidance, and supplier transparency before selecting a source. Products discussed in this article are intended for laboratory research use only and are not intended for human or animal consumption.

What Does “Buy AICAR Online” Mean in a Research Context?

The phrase “buy AICAR online” is addressed here as laboratory research procurement intent, not personal-use intent. A qualified laboratory buyer is usually trying to confirm whether an AICAR research material is accurately labeled, supported by documentation, and supplied with enough lot-level information to fit internal purchasing controls.

Research-use-only procurement is different from consumer buying. The relevant questions are not use outcomes, preparation steps, or biological claims. The relevant questions are whether the supplier clearly states RUO status, whether the AICAR COA is batch-specific, whether the product name and lot number match the documentation, whether purity and identity testing are described, and whether storage and handling information is available. FDA guidance on RUO labeling in the in vitro diagnostic context illustrates the broader compliance principle that RUO labeling must not be used to position materials for clinical diagnostic use.[1]

For AICAR procurement, supplier transparency also includes avoiding personal-use language. A research-focused supplier should not frame AICAR as a therapy, supplement, consumer wellness material, or veterinary material. The page should make clear that the material is intended for controlled laboratory settings and documentation review by qualified researchers and technical procurement teams.

AICAR Research Material Overview

AICAR is commonly associated with acadesine or AICA riboside terminology in scientific databases and literature. PubChem lists acadesine under the formula C9H14N4O5 and identifies AICAR among its names and synonyms, while ChEMBL lists ACADESINE as a small molecule with molecular weight 258.23.[2] [3] The National Cancer Institute Drug Dictionary describes acadesine as a 5-aminoimidazole-4-carboxamide riboside, a purine nucleoside analog, and a nucleotide biosynthesis precursor, and notes that it can be phosphorylated to AICA ribotide, also known as ZMP.[4]

Database records are useful for identity review because AICAR naming can vary across research settings. HMDB lists AICA-riboside, also known as acadesine or AICAR, and the IUPHAR/BPS Guide to Pharmacology lists acadesine with synonyms including AICA-riboside and SCH-900395.[5] [6] Researchers should therefore compare the supplier’s product name, synonym set, molecular formula, and documentation against recognized database identifiers rather than relying on a product title alone.

AICAR is not a peptide sequence; it is generally treated as a small-molecule nucleoside-related research compound. In research literature, AICA riboside became widely used as a tool compound in AMPK-related cellular signaling studies after early work describing activation of AMP-activated protein kinase in intact cells.[7] AMPK itself is described in review literature as a cellular nutrient and energy sensor, but that pathway context is scientific background and not a product-use claim for an RUO material.[8] A separate preclinical rat muscle study also examined AICA riboside in AMPK-related research, reinforcing that the literature is model-specific scientific context rather than procurement guidance.[9]

Why Researchers Search “Buy AICAR Online”

Researchers search “buy AICAR online” when they need to evaluate RUO product availability, not consumer directions. A procurement team may be comparing product form, AICAR supplier documentation, available COA information, lot traceability, storage notes, purity claims, and identity testing methods. The search often begins with commercial language, but the decision process should remain a documentation-driven laboratory review.

A laboratory buyer looking to buy AICAR should ask whether the supplier states the intended research-use-only status clearly, provides batch-specific documentation, identifies the product as AICAR 50mg or another specific fill size consistently across page, label, and COA, and avoids language that would blur RUO boundaries. A supplier page that emphasizes analytical testing and recordkeeping is more aligned with research procurement than a page built around personal-use claims.

Because AICAR is discussed in AMPK-pathway literature, procurement pages must be especially careful. Scientific context may explain why researchers recognize the compound name, but published pathway studies are not instructions for using a commercial RUO product. Researchers should separate “AICAR appears in published literature” from “this product is appropriate for any biological or clinical purpose.” Only the first statement is acceptable for this procurement guide.

Research Procurement Checklist for AICAR

  • Verify that AICAR is labeled for research use only.
  • Review the available batch-specific certificate of analysis before procurement.
  • Confirm that the AICAR COA includes purity documentation and identity information.
  • Check whether HPLC, LC-MS, mass spectrometry, or another analytical method is listed.
  • Compare the product name, amount, lot number, and documentation for consistency.
  • Assess whether the supplier avoids dosing, therapeutic, personal-use, or veterinary-use claims.
  • Document storage and handling information in laboratory purchasing records.
  • Evaluate whether lyophilized powder form matches the needs of the research workflow.
  • Confirm that the product is not marketed for human or animal consumption.

AICAR Quality Signals to Review Before Buying Online

When researchers evaluate where to buy AICAR online for laboratory research, quality signals should be assessed as a package rather than as isolated claims. A purity percentage, a product title, or a broad statement about testing is less informative than a consistent set of RUO labeling, lot-specific COA data, identity testing, storage documentation, and supplier language.

Evaluation Area What Researchers Should Review Why It Matters for RUO Procurement
RUO labeling Confirm the product is clearly labeled for research use only Helps separate research procurement from human-use positioning
COA availability Review the available batch-specific certificate of analysis Supports lot-level documentation and quality review
Purity data Look for analytical support for the stated purity Helps evaluate material consistency
Identity testing Review HPLC, LC-MS, mass spectrometry, or related identity data when listed Helps confirm the material matches the listed compound
Lot traceability Match lot numbers across product and documentation Supports research recordkeeping
Product form Confirm whether the material is supplied as lyophilized powder or another documented form Supports laboratory planning
Storage information Review storage and handling documentation Helps maintain material integrity in laboratory settings
Supplier language Confirm the supplier avoids dosing, therapeutic, or personal-use claims Supports research-use-only positioning

COA, Purity, and Identity Documentation

For AICAR procurement, the COA should be reviewed together with the product page and label. Researchers should look for compound name, amount, lot number, test date, purity percentage, analytical method, identity confirmation, molecular weight or formula references when listed, product form, and storage documentation. A purity percentage alone does not establish complete compound identity; researchers should evaluate purity, identity, method, lot number, and documentation together.

Analytical-method review matters because HPLC, LC-MS, and mass spectrometry answer different documentation questions. FDA’s Q2(R2) analytical validation guidance describes validation concepts for analytical procedures, while Q14 addresses science- and risk-based analytical procedure development.[10] [11] Mass spectrometry resources from NIST describe reference mass spectral data as tools that assist compound identification, and analytical chemistry literature discusses the value and limits of mass spectral library searching for chemical identification.[12] [13]

For procurement records, the strongest review is practical: confirm that the product label and COA refer to the same lot, that the AICAR identity testing is stated in a way the laboratory can document, and that the supplier’s language remains research-use-only. If any element is missing or inconsistent, the procurement record should note the gap before the material enters a research workflow.

flowchart TD A[Receive product and COA] --> B{RUO labeling present?} B -- No --> C[Flag procurement gap] B -- Yes --> D{Lot number matches across label and COA?} D -- No --> E[Request batch-specific documentation] D -- Yes --> F{Identity supported by analytical method?} F -- No --> G[Request HPLC, LC-MS, or equivalent] F -- Yes --> H[Proceed to laboratory documentation and storage]

Research Literature Context

Published literature discusses AICA riboside, acadesine, AICAR, and ZMP terminology in AMPK-related research, purine pathway context, model-system experiments, and analytical or database records. A review by Guigas and colleagues emphasized the search for more specific AMPK activators beyond AICA riboside, while a later systematic review by Visnjic and colleagues emphasized that AICAr has important AMPK-independent effects and that AICAr-based studies require careful interpretation.[14] [15]

That caution is especially important for RUO procurement. Research literature may describe pathway models, cell systems, animal models, or clinical studies outside the scope of this product page. Those sources may be relevant to scientific background, but they should not be converted into claims about AICAR 50mg, Pure Lab Peptides products, or any intended use of an RUO material. Metabolic pathway literature should not be translated into weight-loss, performance, or wellness claims for RUO materials.

Some AICAR literature also highlights method limitations. For example, Guigas and colleagues reported AMPK-independent effects in hepatic mitochondrial oxidative phosphorylation models, and Hasenour and colleagues reported model-specific findings in hepatic AMPK research.[16] [17] Gadalla and colleagues examined AICA riboside in rat hippocampal model systems, illustrating how literature can be tissue- and model-specific rather than product-specific.[18]

Published clinical literature should not be interpreted as use guidance for RUO materials. Human-study and clinical-trial publications involving acadesine or AICAR terminology exist, including a study in healthy men and the RED-CABG randomized trial in coronary artery bypass grafting, but those publications are outside the scope of research-use-only product procurement and should not be used to infer instructions, suitability, or intended use for laboratory materials.[19] [20] Broader AMPK review literature provides pathway context, not product-use guidance.[21] [22]

Evidence Landscape

Research Area What Literature Examines Evidence Type RUO Interpretation
Compound identity Molecular structure, formula, synonyms, and classification Database / analytical Supports identification, not product-use claims
Pathway or category context AMPK-related signaling, purine pathway terminology, and model-specific research areas Review / in vitro / preclinical Useful for research context, not therapeutic claims
Analytical testing Purity, identity, and batch verification HPLC / LC-MS / mass spectrometry / COA Supports documentation review
Storage and stability Material form and handling considerations Laboratory documentation Supports research workflow planning

Claim Boundary Table

Research-Safe Statement Why It Is Acceptable Non-Compliant Version to Avoid
“AICAR is discussed in published research related to AMPK pathway and purine nucleoside analog research.” Describes literature context without making a product claim “AICAR helps with a human outcome.”
“Researchers should review AICAR COA and identity data before procurement.” Focuses on documentation and quality review “Users should buy AICAR for results.”
“Pure Lab Peptides supplies AICAR as a research-use-only material.” Clarifies intended use “Pure Lab Peptides supplies AICAR for therapy.”
“The phrase buy AICAR online is addressed as research procurement intent.” Qualifies commercial search intent “Buy AICAR online for personal use.”
“AICAR identity testing should be reviewed alongside purity documentation.” Connects analytical review to procurement records “A purity number proves everything needed for use.”

How Pure Lab Peptides Presents AICAR

Pure Lab Peptides presents AICAR 50mg as a research-use-only material for qualified laboratory procurement. The product is supplied as lyophilized powder with a ≥99% purity claim, and a batch-specific COA is available for documentation review. Researchers should review the product page, labeling, purity information, storage and handling documentation, and lot-level traceability before adding the material to procurement records.

Review the Pure Lab Peptides AICAR research-use-only product page for RUO labeling, product details, purity information, and batch-specific documentation. Teams comparing RUO materials can also review the broader research peptide collection, the Pure Lab Peptides blogs, and shipping and returns information for supplier transparency and purchasing context.

Common Misunderstandings About Buying AICAR Online

Misunderstanding: “Buy AICAR online” means personal use

Buy AICAR online should not be interpreted as personal-use guidance on this page. The phrase is addressed as laboratory procurement intent for qualified researchers reviewing RUO labeling, documentation, purity data, identity information, and supplier transparency.

Misunderstanding: Published literature equals product-use guidance

Published literature may explain why AICAR appears in scientific discussions, but it does not convert an RUO material into a clinical, consumer, or veterinary product. Literature context belongs in research planning and documentation review, not in personal-use instructions.

Misunderstanding: Purity percentage alone proves identity

An AICAR purity documentation statement is important, but it is not the same as complete compound identity confirmation. Researchers should review purity, identity testing, analytical method, lot number, product name consistency, and COA documentation together.

Misunderstanding: COA documentation does not need to be batch-specific

A generic document is less useful than a batch-specific COA tied to the material being procured. Researchers should match the lot number on the product label and COA so internal records reflect the actual batch received.

Misunderstanding: Supplier claims can replace analytical documentation

Supplier language is not a substitute for AICAR identity testing or AICAR supplier documentation. A research procurement review should prioritize COA availability, method information, lot traceability, and storage documentation over broad claims.

FAQs About Buying AICAR Online for Research

Where can researchers buy AICAR online for laboratory research?

Researchers can buy AICAR online for laboratory research from an RUO supplier that provides clear labeling, batch-specific COA documentation, purity information, identity data, and storage guidance. Pure Lab Peptides provides an AICAR 50mg product page for qualified laboratory buyers reviewing research-use-only procurement details.

What should researchers check before buying AICAR online?

Before buying AICAR online, researchers should check RUO labeling, the AICAR COA, product name consistency, purity documentation, identity testing, lot number matching, lyophilized powder form, and storage information. Supplier language should remain focused on laboratory research procurement rather than personal-use or therapeutic positioning.

Why does a COA matter when buying AICAR?

A COA matters when buying AICAR because it supports lot-level documentation and analytical review. The COA should be assessed with the product label and product page so the laboratory can document compound name, lot number, purity statement, testing method, and identity information.

Is AICAR intended for human or animal consumption?

No. AICAR discussed on this page is a research-use-only laboratory material and is not intended for human or animal consumption. This article addresses AICAR research-use-only procurement, supplier documentation, COA review, purity information, identity testing, and lot traceability for controlled laboratory settings.

What does research use only mean for AICAR?

Research use only means AICAR is positioned for qualified laboratory research and documentation workflows, not for consumer, clinical, diagnostic, therapeutic, or veterinary use. RUO review should focus on labeling, batch-specific COA access, analytical documentation, product form, storage guidance, and supplier transparency.

How should published literature about AICAR be interpreted?

Published literature about AICAR should be interpreted as scientific context, not as product-use guidance for RUO materials. Researchers may review database records, analytical sources, and model-system studies to understand terminology and research categories, but procurement decisions should remain documentation-driven and RUO-compliant.

Next Steps

Qualified researchers evaluating AICAR should review product labeling, COA status, identity documentation, purity information, storage notes, and supplier transparency. For research teams comparing AICAR suppliers, prioritize available batch-specific documentation, RUO positioning, and lot-level traceability before selecting any research-use-only material.

References

  1. U.S. Food and Drug Administration. “Distribution of In Vitro Diagnostic Products Labeled for Research Use Only or Investigational Use Only.” FDA Guidance Document. 2013. fda.gov
  2. National Center for Biotechnology Information. “Acadesine.” PubChem Compound Summary. 2026. pubchem.ncbi.nlm.nih.gov/compound/Acadesine
  3. European Bioinformatics Institute. “ACADESINE (CHEMBL1551724).” ChEMBL. 2026. ebi.ac.uk/chembl/explore/compound/CHEMBL1551724
  4. National Cancer Institute. “Acadesine.” NCI Drug Dictionary. 2026. cancer.gov
  5. Wishart Research Group. “AICA-riboside (HMDB0062179).” Human Metabolome Database. 2026. hmdb.ca/metabolites/HMDB0062179
  6. IUPHAR/BPS Guide to Pharmacology. “Acadesine.” Guide to Pharmacology Ligand Database. 2026. guidetopharmacology.org
  7. Corton JM, Gillespie JG, Hawley SA, Hardie DG. “5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?” European Journal of Biochemistry. 1995;229:558-565. pubmed.ncbi.nlm.nih.gov/7744080
  8. Hardie DG, Ross FA, Hawley SA. “AMPK: a nutrient and energy sensor that maintains energy homeostasis.” Nature Reviews Molecular Cell Biology. 2012;13:251-262. pubmed.ncbi.nlm.nih.gov/22436748
  9. Merrill GF, Kurth EJ, Hardie DG, Winder WW. “AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle.” American Journal of Physiology. 1997;273:E1107-E1112. pubmed.ncbi.nlm.nih.gov/9435525
  10. U.S. Food and Drug Administration. “Q2(R2) Validation of Analytical Procedures.” FDA Guidance Document. 2024. fda.gov
  11. U.S. Food and Drug Administration. “Q14 Analytical Procedure Development.” FDA Guidance Document. 2024. fda.gov
  12. National Institute of Standards and Technology. “Mass Spectrometry Data Center.” NIST Chemical Data. 2026. chemdata.nist.gov
  13. Stein S. “Mass Spectral Reference Libraries: An Ever-Expanding Resource for Chemical Identification.” Analytical Chemistry. 2012;84(17):7274-7282. doi.org/10.1021/ac301205z
  14. Guigas B, Sakamoto K, Taleux N, Reyna SM, Musi N, Viollet B, Hue L. “Beyond AICA riboside: in search of new specific AMP-activated protein kinase activators.” IUBMB Life. 2009;61(1):18-26. pubmed.ncbi.nlm.nih.gov/18798311
  15. Visnjic D, Lalic H, Dembitz V, Tomic B, Smoljo T. “AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review.” Cells. 2021;10(5):1095. doi.org/10.3390/cells10051095
  16. Guigas B, Taleux N, Foretz M, Detaille D, Andreelli F, Viollet B, Hue L. “AMP-activated protein kinase-independent inhibition of hepatic mitochondrial oxidative phosphorylation by AICA riboside.” Biochemical Journal. 2007;404(3):499-507. pubmed.ncbi.nlm.nih.gov/17324122
  17. Hasenour CM, Ridley DE, Hughey CC, James FD, Donahue EP, Shearer J, Viollet B, Foretz M, Wasserman DH. “5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) effect on glucose production, but not energy metabolism, is independent of hepatic AMPK in vivo.” Journal of Biological Chemistry. 2014;289:5950-5959. pubmed.ncbi.nlm.nih.gov/24403081
  18. Gadalla AE, Pearson T, Currie AJ, Dale N, Hawley SA, Sheehan M, Hirst W, Michel AD, Randall A, Hardie DG, Frenguelli BG. “AICA riboside both activates AMP-activated protein kinase and competes with adenosine for the nucleoside transporter in the CA1 region of the rat hippocampus.” Journal of Neurochemistry. 2004;88:1272-1282. pubmed.ncbi.nlm.nih.gov/15009683
  19. Cuthbertson DJ, Babraj JA, Mustard KJ, Towler MC, Green KA, Wackerhage H, Leese GP, Baar K, Thomason-Hughes M, Sutherland C, Hardie DG, Rennie MJ. “5-Aminoimidazole-4-Carboxamide 1-beta-D-Ribofuranoside Acutely Stimulates Skeletal Muscle 2-Deoxyglucose Uptake in Healthy Men.” Diabetes. 2007;56:2078-2084. pubmed.ncbi.nlm.nih.gov/17513706
  20. Newman MF, Ferguson TB, White JA, Ambrosio G, Koglin J, Nussmeier NA, Pearl RG, Pitt B, Wechsler AS, Weisel RD, Reves JG. “Effect of Adenosine-Regulating Agent Acadesine on Morbidity and Mortality Associated With Coronary Artery Bypass Grafting: The RED-CABG Randomized Controlled Trial.” JAMA. 2012;308(2):157-164. doi.org/10.1001/jama.2012.7633
  21. Herzig S, Shaw RJ. “AMPK: guardian of metabolism and mitochondrial homeostasis.” Nature Reviews Molecular Cell Biology. 2018;19:121-135. doi.org/10.1038/nrm.2017.95
  22. Hardie DG, Schaffer BE, Brunet A. “AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs.” Trends in Cell Biology. 2016;26(3):190-201. pubmed.ncbi.nlm.nih.gov/26616193

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