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MOTS-C 40mg

$349.99

(5.0) (20 customer reviews)

Research Studies:

  • Facilitates AMPK activation by inhibiting the folate cycle and inducing AICAR accumulation assays
  • Supports investigation into stress-induced nuclear translocation and antioxidant response element gene expression
  • Enables research on GLUT4 translocation and fatty acid oxidation in metabolic homeostasis models
  • Useful for evaluating myostatin inhibition through the AKT-FOXO1 and mTORC2 signaling pathways

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ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are intended solely for research and laboratory use. These products are not intended for human or animal consumption. They are not medicines or drugs and have not been evaluated or approved by the FDA to diagnose, treat, cure, or prevent any disease or medical condition. Any form of bodily introduction is strictly prohibited by law.

Description

MOTS-C 40mg is a research-use-only laboratory material supplied for controlled research workflows, compound characterization, and analytical documentation review. It is manufactured under rigorous quality standards to support consistency, traceability, and batch-specific verification for qualified laboratory settings.

Key Product Details

  • Manufactured in accordance with rigorous quality standards to support ≥99% purity, as reflected in batch-specific documentation where available.
  • Every batch is third-party analyzed for identity, assay/potency, and sterility documentation where applicable.
  • Supplied in lyophilized powder form to help preserve stability throughout transport and storage.
  • Produced with lot-level traceability to support research documentation and laboratory recordkeeping.

Research Documentation Context

  • Supports compound characterization in controlled laboratory settings.
  • Provides batch-specific identity and purity documentation for research review.
  • Allows lot-level traceability across laboratory documentation workflows.
  • Supports comparison of product labeling, analytical documentation, and storage information during research planning.
  • Supports analytical review of peptide research materials within a strictly laboratory-focused context.

Specifications and Documentation

  • Certificate of Analysis: Available with batch-specific documentation where applicable.
  • Material Safety Data Sheet: Coming Soon.
  • Handling and Storage Instructions: Coming Soon.
  • Product Form: Lyophilized powder.
  • Purity Specification: ≥99% purity.
  • Intended Use: Laboratory research use only.

MOTS-C 40mg is intended strictly for laboratory research use only. This product is not intended for human or animal consumption, therapeutic use, diagnostic use, clinical use, veterinary use, or as a food, drug, cosmetic, dietary supplement, or household product.

Additional information

CAS No.

1627580-64-6

Purity

≥99%

Sequence

Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg

Molecular Formula

C101H152N28O22S2

Molecular Weight

2174.6 g/mol

Applications

Metabolic regulation research, insulin sensitivity studies, exercise physiology and aging research

Synthesis

Solid-phase synthesis

Format

Lyophilized powder

Solubility

Soluble in water or 1% acetic acid

Stability & Storage

Stable for up to 24 months at -20°C. After reconstitution, may be stored at 4°C for up to 4 weeks or at -20°C for up to 6 months.

Appearance

White lyophilized powder

Safety Information

Refer to provided MSDS

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Research Procurement Information

Buy MOTS-c Online for Research | COA Guide

Researchers searching for buy MOTS-c online should evaluate MOTS-c as a research-use-only laboratory material, not a consumer product. For laboratory buyers, the key considerations are compound identity, MOTS-c COA review, purity documentation, lot traceability, product labeling, storage information, and supplier evaluation. This guide explains how to evaluate MOTS-c for controlled research procurement through Pure Lab Peptides while keeping published literature separate from any product-use claim.

Fast Answer: buy MOTS-c online for laboratory research

Researchers can buy MOTS-c online for laboratory research by reviewing RUO labeling, batch-specific COA documentation, purity data, identity information, storage guidance, and supplier transparency before selecting a source. Products discussed in this article are intended for laboratory research use only and are not intended for human or animal consumption.

What Does “Buy MOTS-c Online” Mean in a Research Context?

The phrase buy MOTS-c online is addressed here as laboratory research procurement intent, not personal-use intent. In that context, the search is about whether a qualified laboratory buyer can review the identity of the MOTS-c research material, confirm research-use-only labeling, evaluate the batch-specific certificate of analysis, and document the supplier record before procurement.

Regulatory discussions of RUO labeling distinguish laboratory research positioning from diagnostic or clinical positioning; FDA guidance for RUO in vitro diagnostic products and the corresponding federal labeling provision are useful boundary references for understanding why labeling language matters, even though a research peptide procurement page is not an IVD instruction page [1] [2]. For peptide procurement, the same practical discipline applies: review the intended-use label, verify product and lot documentation, and avoid suppliers that blur research materials with consumer, therapeutic, diagnostic, or veterinary positioning.

A research procurement workflow should also preserve internal records. Laboratory buyers commonly need a product page record, invoice or purchase record, batch-specific COA, receiving record, and storage record that all point to the same product and lot. This documentation chain supports internal review even when no regulatory submission is involved. It also helps technical teams distinguish the supplier’s stated identity from the laboratory’s own downstream experimental design.

MOTS-c Research Material Overview

MOTS-c is commonly discussed as a mitochondrial-derived peptide. PubChem lists MOTS-c under compound CID 146675088 with the molecular formula C101H152N28O22S2, and UniProt identifies the human MOTS-c entry as a mitochondrial-derived peptide sequence record [3] [4]. NCBI Gene records identify the human RNR1 / MT-RNR1 locus as mitochondrially encoded 12S rRNA, the mitochondrial region discussed in the MOTS-c literature [5].

In published research, MOTS-c appears in literature related to mitochondrial open reading frames, mitochondrial-derived peptide biology, and model-specific studies of AMPK-linked pathways [6]. Later work examined the peptide as a mitochondrial-encoded signal that can be studied in relation to nuclear gene-expression models under defined experimental conditions [7] [8]. Review literature summarizes MOTS-c as a 16-amino-acid mitochondrial-derived peptide while also emphasizing that research interpretation depends on model type, assay design, and study limitations [9].

For procurement purposes, these scientific descriptors help laboratories confirm that the listed research material matches the expected compound name, molecular identity, and analytical documentation. They do not create instructions for personal use, therapeutic use, clinical application, or animal use.

Why Researchers Search “Buy MOTS-c Online”

Researchers search buy MOTS-c online to compare research-use-only availability, product form, supplier documentation, and lot-level transparency. A compliant search result should help a laboratory buyer determine whether a MOTS-c research-use-only product is clearly labeled, whether the MOTS-c COA is available for the relevant batch, whether the purity claim is supported by analytical data, and whether the product page avoids medical, consumer, or performance-oriented claims.

The secondary phrase buy MOTS-c should be interpreted in the same narrow way on this page: procurement review for qualified researchers. The procurement decision should be based on MOTS-c supplier documentation, lot number consistency, storage information, product form, and batch-specific records, not on expected outcomes or off-label use narratives.

For procurement teams, the commercial search query often has a practical purpose: finding a supplier page that can be evaluated by a laboratory manager, purchasing department, principal investigator, or quality reviewer. A useful page should state the product name, amount, form, purity claim, documentation status, and intended-use boundary clearly enough that the buyer can route the material through an internal purchasing workflow without relying on promotional claims.

Research Procurement Checklist for MOTS-c

  • Verify that MOTS-c is labeled for research use only.
  • Review the batch-specific certificate of analysis before procurement.
  • Confirm that the COA includes MOTS-c purity documentation and identity information for the applicable lot.
  • Check whether HPLC, LC-MS, mass spectrometry, or another analytical method is listed in the documentation.
  • Compare the product name, lot number, and documentation for consistency.
  • Assess whether the supplier avoids dosing, therapeutic, diagnostic, veterinary, or personal-use claims.
  • Document storage and handling information in laboratory records.
  • Evaluate whether lyophilized powder form matches the needs of the research workflow.
  • Confirm that the product is not marketed for human or animal consumption.

MOTS-c Quality Signals to Review Before Buying Online

Researchers evaluating buy MOTS-c online for laboratory research should prioritize documentation signals over promotional language. Analytical methods should be interpreted together: FDA guidance notes that analytical procedures and validation data can support documentation of identity, purity, and quality attributes, while ICH Q2(R2) and Q14 describe validation and procedure-development principles relevant to method review [10] [11] [12].

Quality signals should be read as a group. RUO labeling without analytical support is incomplete, and a purity statement without a matching lot record is weak procurement evidence. Similarly, an analytical method name is more useful when it is connected to the product name, batch number, and test date. Strong MOTS-c supplier documentation makes those relationships easy to verify.

Evaluation Area What Researchers Should Review Why It Matters for RUO Procurement
RUO labeling Confirm the product is clearly labeled for research use only Helps separate research procurement from human-use positioning
COA availability Review the batch-specific certificate of analysis for the lot being evaluated Supports lot-level documentation and quality review
Purity data Look for analytical support for the stated purity Helps evaluate material consistency
Identity testing Review HPLC, LC-MS, mass spectrometry, or related identity data listed in the documentation Helps confirm the material matches the listed compound
Lot traceability Match lot numbers across product and documentation Supports research recordkeeping
Product form Confirm whether the material is supplied as lyophilized powder or another documented form Supports laboratory planning
Storage information Review storage and handling documentation Helps maintain material integrity in laboratory settings
Supplier language Confirm the supplier avoids dosing, therapeutic, diagnostic, veterinary, or personal-use claims Supports research-use-only positioning

COA, Purity, and Identity Documentation

A MOTS-c COA should be reviewed as a batch-specific document, not as a generic quality statement. Researchers should check the compound name, lot number, test date, purity percentage, testing method, identity confirmation, product form, and any chromatogram or mass data included in the batch-specific documentation. Laboratories that rely on outside testing records may also review whether the testing environment is described with appropriate competence and traceability expectations; ISO/IEC 17025 is a widely cited standard for testing and calibration laboratory competence [13].

A purity percentage alone does not establish complete compound identity; researchers should evaluate purity, identity, method, lot number, and documentation together. HPLC is widely used for peptide analysis and purification, while LC-HRMS has been described as an approach for peptide quality control and peptide-related impurity characterization [14] [15]. These method references explain why a MOTS-c purity documentation review should consider both separation behavior and mass-based identity support.

For a MOTS-c 40mg lyophilized powder procurement record, the documentation review should also verify that the amount and product form listed on the product page align with the COA and internal receiving notes. If a laboratory archives screenshots or supplier documents, those records should be dated and connected to the lot received. This is a documentation practice, not a use protocol.

flowchart TD A[Receive product and COA] --> B{RUO labeling present?} B -- No --> C[Flag procurement gap] B -- Yes --> D{Lot number matches across label and COA?} D -- No --> E[Request batch-specific documentation] D -- Yes --> F{Identity supported by analytical method?} F -- No --> G[Request HPLC, LC-MS, or equivalent] F -- Yes --> H[Proceed to laboratory documentation and storage]

Research Literature Context

Published literature has examined MOTS-c in mitochondrial-derived peptide research, cellular signaling models, and preclinical research models. A 2016 review describes MOTS-c as a mitochondrial-derived peptide involved in model-specific studies of muscle and adipose pathway biology [16]. A 2023 review summarizes mechanisms discussed in stress-response and AMPK-related research contexts [17], and another review surveys MOTS-c within broader mitochondrial-derived peptide literature [18].

Some literature also discusses genetic variation, endogenous peptide measurements, or model-specific pathway findings. For example, a commentary considered MOTS-c in a mitochondrial DNA polymorphism context, and MOTS-c-specific mass spectrometry work has been published for detection-method development in plasma samples [19] [20]. More recent work has examined possible protein-interaction models such as CK2 binding, while other studies analyze MOTS-c in age-related or physical-decline model systems [21] [22].

Published clinical literature should not be interpreted as use guidance for RUO materials. Metabolic pathway literature should not be translated into weight-loss, performance, or wellness claims for RUO materials. For this article, the scientific literature is used only to frame compound identity, category, pathway context, analytical interpretation, and documentation review.

The evidence landscape is therefore mixed by design: database records support molecular identification, analytical literature supports testing interpretation, reviews summarize research categories, and model studies provide scientific context. None of those categories replace the need for a batch-specific MOTS-c COA. A laboratory buyer should treat the literature and the product documentation as separate records with different purposes.

Evidence Landscape

Research Area What Literature Examines Evidence Type RUO Interpretation
Compound identity Molecular structure, sequence, formula, and mitochondrial-derived peptide classification Database / analytical Supports identification, not product-use claims
Pathway or category context Mitochondrial-derived peptide literature and AMPK-pathway model research Review / in vitro / preclinical Useful for research context, not therapeutic claims
Analytical testing Purity, identity, and batch verification HPLC / LC-MS / mass spectrometry / COA Supports documentation review
Storage and stability Material form and handling considerations Laboratory documentation Supports research workflow planning

Claim Boundary Table

Research-Safe Statement Why It Is Acceptable Non-Compliant Version to Avoid
“MOTS-c is discussed in published research related to mitochondrial peptide and AMPK-pathway model research.” Describes literature context without making a product claim “MOTS-c helps with a human outcome.”
“Researchers should review COA and identity data before procurement.” Focuses on documentation and quality review “Users should buy MOTS-c for results.”
“Pure Lab Peptides supplies MOTS-c as a research-use-only material.” Clarifies intended use “Pure Lab Peptides supplies MOTS-c for therapy.”
“The phrase buy MOTS-c online is addressed as research procurement intent.” Qualifies commercial search intent “Buy MOTS-c online for personal use.”
“MOTS-c identity testing should be reviewed with purity and lot documentation.” Connects analytical review with recordkeeping “A purity number alone proves everything needed.”

How Pure Lab Peptides Presents MOTS-c

Pure Lab Peptides presents MOTS-c as a research-use-only compound for laboratory procurement. The MOTS-c 40mg product is supplied as lyophilized powder with a stated ≥99% purity claim, batch-specific COA availability, product page documentation, storage and handling information, lot-level traceability, and supplier transparency.

Because the batch-specific COA is available, researchers should review it in present tense as part of routine procurement due diligence. The COA should be considered alongside the product page, label information, purity claim, identity testing record, and storage guidance. Pure Lab Peptides positioning should be evaluated as RUO supplier documentation, not as clinical, consumer, or veterinary positioning.

Review the Pure Lab Peptides MOTS-c 40mg research-use-only product page for RUO labeling, product details, purity information, and batch-specific documentation. Qualified researchers comparing peptide suppliers can also review the broader research peptide collection, the Pure Lab Peptides blog resources, and shipping and returns information as part of procurement documentation.

Common Misunderstandings About Buying MOTS-c Online

Misunderstanding: “Buy MOTS-c online” means personal use

Buy MOTS-c online should not be interpreted as personal-use guidance on this page. The phrase is addressed as laboratory procurement intent for qualified researchers reviewing RUO labeling, documentation, purity data, identity information, and supplier transparency.

Misunderstanding: Published literature equals product-use guidance

Published literature may help laboratories understand compound category, mitochondrial-derived peptide terminology, and analytical context. It should not be converted into instructions, outcome promises, clinical claims, veterinary claims, or wellness language for an RUO research material.

Misunderstanding: Purity percentage alone proves identity

A purity percentage is one part of documentation review. MOTS-c identity testing, analytical method, lot number, chromatographic or mass-based information, and product name consistency should be evaluated together before a laboratory records the material as fit for a defined research inventory.

Misunderstanding: COA documentation does not need to be batch-specific

COA documentation should be matched to the lot being evaluated. A batch-specific COA helps laboratory buyers connect the material received with the analytical record, supporting traceability, internal recordkeeping, and procurement review.

Misunderstanding: RUO labeling supports clinical, veterinary, or consumer positioning

Research-use-only labeling does not support clinical, diagnostic, veterinary, consumer, or personal-use positioning. It narrows the intended context to controlled laboratory research procurement and related documentation review.

FAQs About Buying MOTS-c Online for Research

Where can researchers buy MOTS-c online for laboratory research?

Researchers can buy MOTS-c online for laboratory research from an RUO supplier that provides clear product labeling, a batch-specific COA, purity documentation, identity information, storage guidance, and lot traceability. Pure Lab Peptides provides a MOTS-c 40mg product page for qualified researchers reviewing these procurement details.

What should researchers check before buying MOTS-c online?

Before buying MOTS-c online, researchers should check RUO labeling, MOTS-c COA availability, lot number consistency, purity documentation, analytical method, product form, storage information, and supplier documentation. The review should focus on research procurement records, not on use outcomes or personal-use claims.

Why does a COA matter when buying MOTS-c?

A COA matters when buying MOTS-c because it connects a specific lot to analytical documentation. Researchers should review the compound name, lot number, test date, purity data, identity method, and product form so the procurement record supports traceable laboratory documentation.

Is MOTS-c intended for human or animal consumption?

MOTS-c discussed here is not intended for human or animal consumption. This page addresses MOTS-c research-use-only sourcing, COA review, purity documentation, identity testing, supplier transparency, and laboratory recordkeeping for qualified research procurement teams.

What does research use only mean for MOTS-c?

Research use only for MOTS-c means the material is positioned for controlled laboratory research procurement and documentation review. It is not positioned for clinical, diagnostic, veterinary, consumer, therapeutic, or personal-use purposes, and procurement language should remain limited to laboratory evaluation.

How should published literature about MOTS-c be interpreted?

Published literature about MOTS-c should be interpreted as scientific context for compound identity, mitochondrial-derived peptide classification, pathway models, and analytical methods. It should not be interpreted as product-use guidance, outcome evidence for a research material, or a substitute for batch-specific COA review.

Next Steps

Qualified researchers evaluating MOTS-c should review product labeling, COA status, identity documentation, storage information, purity documentation, and supplier transparency before selecting any research-use-only material. Review the MOTS-c product page for RUO labeling, purity information, and available batch-specific documentation.

References

  1. U.S. Food and Drug Administration. “Distribution of In Vitro Diagnostic Products Labeled for Research Use Only or Investigational Use Only.” FDA Guidance Document. 2013. fda.gov
  2. Electronic Code of Federal Regulations. “21 CFR 809.10 – Labeling for in vitro diagnostic products.” eCFR. 2026. ecfr.gov
  3. National Center for Biotechnology Information. “PubChem Compound Summary for CID 146675088, Mots-c.” PubChem. 2026. pubchem.ncbi.nlm.nih.gov
  4. The UniProt Consortium. “A0A0C5B5G6 – Mitochondrial-derived peptide MOTS-c (human).” UniProtKB. 2026. uniprot.org
  5. National Center for Biotechnology Information. “RNR1 s-rRNA [Homo sapiens (human)], Gene ID: 4549.” NCBI Gene. 2026. ncbi.nlm.nih.gov/gene/4549
  6. Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, Cohen P. “The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.” Cell Metabolism. 2015;21(3):443-454. doi.org/10.1016/j.cmet.2015.02.009
  7. Kim KH, Son JM, Benayoun BA, Lee C. “The mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress.” Cell Metabolism. 2018;28(3):516-524.e7. doi.org/10.1016/j.cmet.2018.06.008
  8. Benayoun BA, Lee C. “MOTS-c: A mitochondrial-encoded regulator of the nucleus.” BioEssays. 2019;41(9):e1900046. doi.org/10.1002/bies.201900046
  9. Zheng Y, Wei Z, Wang T. “MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation.” Frontiers in Endocrinology. 2023;14:1120533. doi.org/10.3389/fendo.2023.1120533
  10. U.S. Food and Drug Administration. “Analytical Procedures and Methods Validation for Drugs and Biologics.” FDA Guidance Document. 2015. fda.gov
  11. U.S. Food and Drug Administration. “Q2(R2) Validation of Analytical Procedures.” FDA Guidance Document. 2024. fda.gov
  12. U.S. Food and Drug Administration. “Q14 Analytical Procedure Development.” FDA Guidance Document. 2024. fda.gov
  13. International Organization for Standardization. “ISO/IEC 17025 – Testing and calibration laboratories.” ISO. 2017. iso.org
  14. Mant CT, Chen Y, Yan Z, Popa TV, Kovacs JM, Mills JB, Tripet BP, Hodges RS. “HPLC analysis and purification of peptides.” Methods in Molecular Biology. 2007;386:3-55. doi.org/10.1007/978-1-59745-430-8_1
  15. Zeng K, Geerlof-Vidavsky I, Gucinski A, Jiang X, Boyne MT 2nd. “Liquid Chromatography-High Resolution Mass Spectrometry for Peptide Drug Quality Control.” The AAPS Journal. 2015;17(3):643-651. doi.org/10.1208/s12248-015-9730-z
  16. Lee C, Kim KH, Cohen P. “MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism.” Free Radical Biology and Medicine. 2016;100:182-187. doi.org/10.1016/j.freeradbiomed.2016.05.015
  17. Wan W, Zhang L, Lin Y, Rao X, Wang X, Hua F, Ying J. “Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging.” Journal of Translational Medicine. 2023;21(1):36. doi.org/10.1186/s12967-023-03885-2
  18. Mohtashami Z, Singh MK, Salimiaghdam N, Ozgul M, Kenney MC. “MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases.” International Journal of Molecular Sciences. 2022;23(19):11991. doi.org/10.3390/ijms231911991
  19. Fuku N, Pareja-Galeano H, Zempo H, Alis R, Arai Y, Lucia A, Hirose N. “The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity?” Aging Cell. 2015;14(6):921-923. doi.org/10.1111/acel.12389
  20. Knoop A, Thomas A, Thevis M. “Development of a mass spectrometry based detection method for the mitochondrion-derived peptide MOTS-c in plasma samples for doping control purposes.” Rapid Communications in Mass Spectrometry. 2019;33(4):371-380. doi.org/10.1002/rcm.8337
  21. Kumagai H, Kim SJ, Miller B, et al. “MOTS-c modulates skeletal muscle function by directly binding and activating CK2.” iScience. 2024;27(11):111212. doi.org/10.1016/j.isci.2024.111212
  22. Reynolds JC, Lai RW, Woodhead JST, Joly JH, Mitchell CJ, Cameron-Smith D, Lu R, Cohen P, Graham NA, Benayoun BA, Merry TL, Lee C. “MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis.” Nature Communications. 2021;12:470. doi.org/10.1038/s41467-020-20790-0

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