MOTS-c 10 mg: research material

Buy MOTS-C 10 mg for laboratory research, supplied as lyophilized powder in one boxed 3 mL vial.

MOTS-c is a 16-amino-acid mitochondrial-derived peptide associated with a short open reading frame in the mitochondrial 12S ribosomal RNA gene. Research examines its roles in cellular metabolism and stress-responsive signaling.

Choose the material and presentation

This page supplies 10 mg of labeled MOTS-c material. The 5, 10, 20 and 40 mg presentations differ in amount; a larger vial amount does not establish higher purity or a stronger biological response. All four use the listed 3 mL vial capacity, which is separate from material mass.

Match the full peptide identity and supplied chemical form to your method. A shortened fragment, a modified sequence or a blocking reagent may not represent the same material. MOTS-c and SS-31 are different molecules, even though both appear in mitochondrial research.

Other presentations: MOTS-c 5 mg, MOTS-c 20 mg, MOTS-c 40 mg.

MOTS-c in metabolic and cellular-stress research

Discovery and metabolic measurements

Lee and colleagues’ 2015 discovery study examined cultured cells and mouse models. It connected MOTS-c with changes in folate and purine metabolism, AICAR accumulation and AMPK signaling. The investigators combined gene-expression, metabolite and functional measurements rather than relying on a single activity label.

The experiments support specific research questions about cellular metabolism. They do not establish a human weight-loss, exercise-performance or longevity benefit from this catalog product.

Read the original discovery study

Localization during metabolic stress

In a 2018 study, Kim and colleagues observed MOTS-c moving into the nucleus of cultured cells under glucose restriction and other metabolic stress conditions. Microscopy and cellular-fraction measurements showed a time-dependent response. Interventions that inhibited AMPK prevented this nuclear movement in the tested systems.

That distinction matters for study comparisons: total peptide abundance, subcellular location and downstream gene expression are different endpoints. The work describes a cellular response, not a guarantee that any preparation or experimental model will reproduce it.

Read the original nuclear-localization study

Product records and batch reports

Available COA and product files are in the product documentation section. Match the lot and identity, then distinguish chromatographic purity from measured content. Refer to the relevant chemical form when using a molecular weight in concentration calculations.

Use the applicable product records for storage and handling. A paper’s biological results do not establish this lot’s stability, and another supplier’s solvent or storage instructions may concern a different preparation.