KPV 10 mg: research material

Buy KPV 10 mg for laboratory research, supplied as lyophilized powder in one boxed 3 mL vial.

KPV is the tripeptide lysine-proline-valine, corresponding to the C-terminal three-residue sequence of alpha-melanocyte-stimulating hormone (alpha-MSH). It is studied in peptide transport and inflammatory-signaling models.

Choose the material and presentation

This 10 mg product is single-compound KPV. It differs from full-length alpha-MSH and from the KLOW and Tri-Heal blends, whose total mass includes other ingredients. Compare the individual compound amounts when a study calls for KPV alone.

The labeled mass is not a concentration or an experimental dose. Match the peptide identity and any specified terminal chemistry or salt form to your method. The three-letter name identifies the residue sequence; the applicable material records provide the supplied-product details.

KPV uptake and inflammatory signaling

Intestinal epithelial and immune-cell models

Dalmasso and colleagues studied KPV in intestinal epithelial cell lines and Jurkat T cells. They used uptake experiments alongside NF-kappaB reporter, protein and cytokine assays. Their results linked the PepT1 di/tripeptide transporter to cellular uptake and lower activation of selected NF-kappaB and MAP kinase pathways.

The study also examined two chemically induced mouse-colitis models. These experiments help distinguish transport, pathway measurements and tissue-level outcomes. They do not establish a human treatment effect or a dosing schedule for this research material.

Read the original PepT1 study

Mechanism depends on the cell system

In a separate study of immortalized human bronchial epithelial cells, Land compared KPV with gamma-MSH. KPV reduced nuclear entry of the NF-kappaB component p65RelA; gamma-MSH’s response instead required the melanocortin-3 receptor, MC3R, in that model. The work measured reporter activity and inflammatory signaling, including IL-8 and eotaxin secretion.

The comparison shows why a relationship to melanocortin peptides does not imply identical receptor dependence. Record the cell type, stimulus, uptake conditions and measured endpoint when assessing a KPV experiment.

Read the original airway-cell study

Product records and batch reports

Review available lot reports and product files in the product documentation section. Check the product and lot identifiers, then read identity, chromatographic purity and measured content as separate results.

Use the applicable material instructions for handling and storage. A general paper about KPV, or another supplier’s preparation instructions, does not verify this batch’s chemical form, stability or suitability for a particular assay.