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FOXO4-DRI 10 mg (Proxofim) is a synthetic D-retro-inverso peptide engineered to disrupt the FOXO4-p53 interaction that allows senescent cells to resist apoptosis. By reinstating p53-mediated cell death in these cells, FOXO4-DRI functions as a potent senolytic agent in pre-clinical studies, opening new avenues for research into age-related degeneration and chronic inflammatory conditions.
Manufactured under stringent cGMP-like conditions to ensure ≥99 % purity and batch-to-batch consistency.
Lyophilized powder for maximum stability; reconstitutes rapidly in sterile distilled water or buffer.
Extensively validated by HPLC and mass spectrometry for precise molecular integrity.
Investigating senolytic mechanisms and selective clearance of senescent cells.
Exploring therapeutic potential in age-associated tissue dysfunction and metabolic decline.
Assessing downstream effects on oxidative stress, insulin signaling, and cancer cell plasticity.
Material Safety Data Sheet (MSDS): Coming Soon.
Handling and Storage Instructions: Coming Soon.
FOXO4-DRI has emerged as a valuable research tool for probing cellular senescence, regenerative biology, and longevity science, offering investigators a robust platform for advancing anti-aging and disease-modifying strategies.
| CAS No. | 2460055-10-9 |
|---|---|
| Purity | ≥99% |
| Sequence | D-(Leu-Thr-Leu-Arg-Lys-Glu-Pro-Ala-Ser-Glu-Ile-Ala-Gln-Ser-Ile-Leu-Glu-Ala-Tyr-Ser-Gln-Asn-Gly-Trp-Ala-Asn-Arg-Arg-Ser-Gly-Gly-Lys-Arg-Pro-Pro-Pro-Arg-Arg-Arg-Gln-Arg-Arg-Lys-Lys-Arg-Gly) |
| Molecular Formula | C₂₂₈H₃₈₈N₈₆O₆₄ |
| Molecular Weight | 358.06 g/mol |
| Applications | Senescence research, anti-aging studies, degenerative disease models |
| Synthesis | Solid-phase synthesis |
| Solubility | Soluble in water or 1% acetic acid |
| Stability & Storage | Stable for up to 24 months at -20°C. After reconstitution, may be stored at 4°C for up to 4 weeks or at -20°C for up to 6 months. |
| Appearance | White lyophilized powder |
| Shipping Conditions | Shipped at ambient temperature; once received, store at -20°C |
| Regulatory/Compliance | Manufactured in a facility that adheres to cGMP guidelines |
| Safety Information | Refer to provided MSDS |
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