FOXO4-DRI 10 mg: research material

Buy FOXO4-DRI 10 mg for laboratory research, supplied as lyophilized powder in one boxed 3 mL vial.

FOXO4-DRI is a synthetic peptide designed to study the interaction between FOXO4 and p53 in cellular senescence. It is a research construct, not the full-length FOXO4 protein.

Choose the material and presentation

DRI means D-retro-inverso: the design changes residue order and amino-acid stereochemistry relative to the corresponding L-peptide. A native protein, an L-form fragment and a DRI peptide are not interchangeable materials, even when they share the FOXO4 name.

What the FOXO4-p53 study tested

Baar and colleagues used binding experiments, senescent cell cultures and mouse models. Their designed peptide competed with FOXO4 for p53 binding. In the tested cells, they observed changes in p53 localization and apoptosis, or programmed cell death.

The comparison included a corresponding L-peptide and an unrelated DRI peptide, which did not reproduce the same viability result. That makes construct identity especially relevant when interpreting the work. Selectivity in these models does not establish human anti-aging effects or guarantee the same response in another cell system.

Original study

Product records and batch reports

Open the COA and documents tab for the available batch reports and product files. Match the product and lot, then read identity, purity and measured content as separate results.