Epitalon (Epithalon) 10mg

Researchers evaluating Epitalon procurement should review compound identity and lot-specific research-use-only documentation. Epitalon, also indexed as Epithalon, is commonly described as the synthetic tetrapeptide Ala-Glu-Asp-Gly, or AEDG, with PubChem listing the formula C14H22N4O9 and molecular weight of 390.35 g/mol [1]. This guide covers peptide identity, published literature, COA review, analytical testing, and lot traceability. The supplied material is not intended for consumer, clinical, or personal use.

• Epitalon is a short peptide research compound associated with the AEDG amino acid sequence and several naming variants, including Epithalon and Epithalone [1].
• Researchers evaluate the Epitalon peptide through compound identity, peptide sequence documentation, molecular weight review, and batch-specific supplier records [1], [2].
• Published Epitalon research discusses telomere, telomerase, gene expression, pineal, melatonin, circadian, oxidative stress, and model-specific carcinogenesis topics, but those findings must remain separate from product claims [3].
• COA documentation should be reviewed alongside HPLC, LC-MS, mass spectrometry, lot number, date, and labeling consistency rather than treated as a single isolated quality marker [14], [15].
• Telomere and telomerase literature can support research interpretation, but pathway relevance does not create a product-use claim [4], [6].
• Review RUO labeling, supplier documentation, and lot-level records before procurement.
• Products discussed in this article are intended for laboratory research use only and are not intended for human or animal consumption.

Fast Answer: What Should Researchers Check Before They Buy Epitalon for Research?

Researchers looking to buy Epitalon for research should first review RUO labeling, compound identity data, a batch-specific COA, purity testing, identity verification, lot traceability, and storage documentation. Products discussed in this article are intended for laboratory research use only and are not intended for human or animal consumption. Epitalon is documented as the AEDG tetrapeptide, so sequence and molecular records should align across supplier documentation [1], [2].

What Documentation Should Come First?

Start with the compound name, naming variants, molecular identity, and batch-specific COA. PubChem lists Epitalon with the synonym Epithalon and the sequence-related name Ala-Glu-Asp-Gly, which makes naming consistency important when reviewing supplier records [1].

Next, verify that analytical files match the same lot. A COA is more useful when it is batch-specific, method-aware, and aligned with the product label.

Why RUO Labeling Matters Before Procurement?

RUO labeling keeps the page anchored to laboratory research. FDA labeling materials for IVD contexts describe RUO language as tied to products in a laboratory research phase and not represented for diagnostic procedures; this article uses that as a documentation-boundary reference point, not as a peptide-specific approval statement [20].

Epitalon Peptide Research-Use-Only Context

Read Epitalon documentation as a laboratory research record: verify compound identity, analytical methods, and lot-specific results, and assess published studies separately.

What Does RUO Mean for Epitalon Research Materials?

RUO means the material is positioned for controlled laboratory research and documentation review.

Literature on telomeres, telomerase, melatonin, cellular aging, and longevity does not establish non-research uses for the supplied material.

What Is Epitalon in Peptide Research Literature?

Epitalon is a synthetic peptide commonly described as a tetrapeptide made from four amino acids: alanine, glutamic acid, aspartic acid, and glycine [1], [3]. NCATS Inxight also identifies Epitalon by the sequence Ala-Glu-Asp-Gly and notes that most studies were conducted by the institute associated with the compound’s development [2].

Epitalon literature discusses pineal peptides, telomerase, gene expression, and cellular models. These topics provide scientific background, not evidence of the supplied material’s performance.

Compound Identity and Research Classification

The compound is classified as a short synthetic tetrapeptide rather than a protein, antibody, or large biologic. PubChem lists Epitalon under CID 219042 with molecular formula C14H22N4O9 and molecular weight 390.35 g/mol [1].

That identity data gives researchers a baseline for documentation review. The peptide name, synonym set, formula, molecular weight, and sequence should not conflict across the label, COA, and product-page record.

Epitalon and Epithalon Naming Variants

Epitalon and Epithalon are common spelling variants in databases and literature. PubChem lists Epithalon and Epithalone among synonyms for Epitalon [1].

Why Sequence Documentation Matters for a Tetrapeptide?

For a tetrapeptide, sequence order is part of identity. Epitalon is associated with Ala-Glu-Asp-Gly, so documentation should not merely state “peptide” without confirming the specific peptide sequence [1], [2].

Sequence documentation also helps separate identity review from purity review. A purity value can describe chromatographic composition, but it does not replace molecular identity confirmation.

Molecular and Peptide Identity Considerations for Epitalon

Epitalon’s molecular record gives researchers a way to compare product-page data against official and academic sources. PubChem lists the compound formula, molecular weight, synonyms, and structural identifiers, while NCATS provides additional research-development context [1], [2].

A strong supplier record should make this comparison easy. The product listing should not leave researchers guessing which naming variant, sequence, or molecular identity applies.

How Do Amino Acid Sequence Details Support Documentation?

Amino acid sequence details support documentation by anchoring the compound to a defined molecular structure. For Epitalon, the AEDG sequence corresponds to alanine, glutamic acid, aspartic acid, and glycine [1].

This matters because peptide production, labeling, and COA review all depend on identifying the correct research material. A vague peptide label is weaker than a record that includes name, synonym, sequence, formula, and lot details.

Molecular Weight, Formula, and Identity Review

Molecular weight and formula are core identity checkpoints. Epitalon’s listed molecular formula is C14H22N4O9, and its molecular weight is 390.35 g/mol in PubChem [1].

Researchers can compare those values against supplier documentation. Mismatches should be resolved before the material is selected for a laboratory record.

Telomere and Telomerase Research Context

Telomeres are DNA-protein structures at chromosome ends, and telomerase is an enzyme complex involved in adding telomeric repeats under specific biological conditions [6]. These concepts appear often in Epitalon literature, especially in cell culture and telomerase activity discussions [4], [5].

That does not make telomere language a product claim. It is a research context that requires careful evidence interpretation.

What Can Telomere Literature Show in Laboratory Models?

Telomere literature can show how chromosome-end biology is measured and interpreted in defined research systems. NCBI Bookshelf describes telomeres as chromosomal caps that help preserve linear DNA integrity, while de Lange’s review explains how telomere-associated complexes protect chromosome ends [6], [7].

Telomere research provides background understanding. It does not establish outcomes for a supplied research material outside the cited model.

How Is Telomerase Activity Discussed in Research Context?

Khavinson and colleagues reported that Epithalon peptide induced telomerase activity and telomere elongation in human somatic cell cultures [4]. A 2025 Biogerontology article also examined Epitalon and telomere length in cell-line models through telomerase upregulation or ALT activity [5].

A research-safe interpretation is narrow. These are literature findings in defined models, not product-page claims.

Telomere Length and Genomic Stability

Telomere length is connected to genomic stability because chromosome ends need protection from being interpreted as DNA breaks [6], [7].

Pineal, Melatonin, and Circadian Research Background

Epitalon is often described as a pineal peptide because the literature connects it to Epithalamin, a peptide setup associated with pineal gland research [3]. The pineal gland is also central to melatonin secretion and light-dark signaling, according to Endotext [8].

Where Does Pineal Peptide Literature Fit?

Pineal peptide literature provides historical and mechanistic context for Epitalon. A 2025 review describes Epitalon, also known as Epithalon or Epithalone, as the AEDG tetrapeptide synthesized from amino acid composition associated with Epithalamin [3].

That relationship is useful for source discovery. It should not be used to imply that a research material is equivalent to every setup or study context in the literature.

Melatonin and Circadian Rhythm as Literature Context

Endotext describes melatonin as a pineal hormone whose rhythmic production is used as a marker of internal circadian timing [8]. One Epitalon study in senescent monkeys examined melatonin and cortisol secretion patterns as neuroendocrine research endpoints [9].

Cellular Aging and Longevity Model Terminology

Cellular aging and longevity terms appear in the Epitalon literature, especially in papers involving telomeres, gene expression, pineal models, and lifespan-related endpoints [3], [12]. These experimental endpoints do not establish consumer outcomes.

Cellular Senescence and Laboratory Model Boundaries

Cellular senescence is a research term linked to replicative limits, telomere shortening, and DNA damage signaling in cell biology literature [6].

The boundary is straightforward. Cellular model relevance does not become product positioning.

Age-Related Pathway Context Without Product Claims

Age-related research may examine telomere biology, gene expression, oxidative stress, or circadian rhythm in defined models.

The cited research does not establish an aging-related effect for the material supplied.

Oxidative Stress and Antioxidant Enzyme Literature

Oxidative stress and antioxidant enzyme topics appear in broader pineal peptide and telomere literature. NCBI Bookshelf notes that telomere biology is discussed alongside oxidative stress and reactive oxygen species in cellular contexts [6].

What Do Oxidative Stress Models Add to Epithalon Research?

Oxidative stress models help researchers interpret how redox-related endpoints are studied in cells, tissues, or preclinical systems. Kozina and colleagues reported antioxidant properties for pineal peptide research materials including Epitalon and Epithalamin, making the topic relevant to literature review [11].

Antioxidant Enzymes as Mechanistic Literature Markers

Antioxidant enzymes can serve as mechanistic markers in research. They may appear alongside reactive oxygen species, oxidative damage, redox signaling, and gene expression endpoints in laboratory literature [6], [11].

These markers help characterize the models studied. They are not a substitute for batch documentation, peptide identity, or analytical verification.

How Should Researchers Interpret Published Epitalon Findings?

Researchers should interpret Epitalon findings through an evidence ladder: compound identity, in vitro research, preclinical model literature, and broader review context. Each level can support understanding, but none should be converted into product-use guidance.

In Vitro and Cell Culture Evidence Review

In vitro and cell culture studies can provide molecular and pathway signals under controlled laboratory conditions. Khavinson’s 2003 paper reported telomerase activity and telomere elongation in human somatic cell cultures, while the 2025 Biogerontology article examined telomere length in human cell-line models [4], [5].

These models help explain telomerase activity. They do not create conclusions beyond the study context.

What Can Animal Model Literature Contribute?

Animal model literature can show how researchers have examined endpoints such as lifespan, tumor incidence, melatonin, and carcinogenesis in controlled preclinical systems. Anisimov and colleagues reported model-specific tumor incidence findings in mice, while a separate colon carcinogenesis paper examined Epitalon in chemically induced rat models [12], [13].

The value is evidence mapping. The limitation is that preclinical literature is not product positioning.

Where Do Carcinogenesis and Tumor Incidence Models Require Caution?

Findings from carcinogenesis and tumor-incidence models remain specific to the experimental materials and methods. They do not establish outcomes for the supplied research material.

How Research Literature Stays Separate From Product Claims

Published literature is not the same as a product claim.

Some published literature outside the scope of RUO product use has examined this compound class in human study settings. That literature should not be interpreted as a use claim for research-use-only materials.

Why Study Findings Should Not Become Product Claims?

Study findings depend on the models, assay conditions, and limitations reported in each paper. They do not establish what a supplied research material does.

Why Does COA Documentation Matter for Epitalon Peptide Review?

A certificate of analysis matters because it connects a research material to batch-level testing documentation. FDA guidance on analytical procedures states that method validation data can support documentation of identity, quality, purity, and related quality attributes in regulated drug and biologic contexts; for RUO peptide pages, that principle is useful as a documentation framework rather than a regulatory claim [14].

For Epitalon, a COA should help researchers compare name, lot number, analytical method, purity data, and identity data.

What Should a Certificate of Analysis Show?

A useful COA should show the compound name, lot number, testing date, analytical method, purity result, and identity-supporting data. It should also align with the peptide identity record for Epitalon as AEDG [1].

A COA is strongest when it is batch-specific. A generic file is less useful for procurement review.

How Should Researchers Review COA Consistency?

Researchers should compare the COA against the product label and product listing. The compound name, synonym, molecular weight, and lot number should not conflict.

The COA should also make the analytical basis clear. ICH Q2(R2), adopted by FDA, describes analytical procedure validation as a framework for showing that an analytical procedure is fit for its intended purpose [15].

HPLC, LC-MS, and Analytical Verification Workflow

HPLC and LC-MS serve different documentation roles. HPLC is widely used for peptide separation and purity-related review, while LC-MS combines liquid chromatography with mass spectrometry for molecular identification and quantitation workflows [17], [18].

For Epitalon, analytical verification is strongest when purity and identity evidence are both present.

Documentation verification sequence:

1. Verify that the compound name, lot number, and label match across product records.
2. Review the batch-specific certificate of analysis.
3. Check whether the purity testing method is listed.
4. Confirm whether identity testing is supported by LC-MS or another suitable analytical method.
5. Review chromatogram or mass data when available.
6. Check the COA date and testing source.
7. Document storage and handling requirements in a laboratory record.

How Does HPLC Support Peptide Purity Review?

HPLC supports peptide purity review by separating peptide-related components under defined chromatographic conditions. Mant and Hodges describe HPLC as a versatile method for peptide isolation and purification across peptide types and complexity levels [17].

For a COA, the key is not only the purity number. Researchers should also review whether the method, chromatogram, and lot match the product record.

How Does LC-MS Support Peptide Identity Confirmation?

LC-MS can support peptide identity confirmation by connecting chromatographic separation with mass spectrometry data. Mass spectrometry reports ions by mass-to-charge ratio, and NIST defines mass-to-charge ratio as the mass of an ion divided by its charge [19].

For Epitalon, LC-MS documentation should be read alongside the expected molecular identity. PubChem’s molecular weight record gives a reference point for that review [1].

What Supplier Documentation Supports Epitalon Procurement?

Supplier records help researchers evaluate whether the listing is technically complete. Review RUO labeling, COA access, analytical method information, lot-level traceability, and storage records.

FDA’s Q14 guidance describes science-based and risk-based approaches for analytical procedure development in regulated quality contexts; for RUO pages, that supports the broader principle that method documentation should be clear and maintainable [16].

Lot Traceability and Research Material Records

Lot traceability links the product label, COA, testing file, and supplier record. FDA IVD labeling materials also identify lot or control number traceability as part of general-purpose reagent labeling context [20].

For peptide research procurement, a lot number should not be treated as a minor detail. It is the connection point between the physical research material and its documentation trail.

Why Does Labeling Consistency Matter for Epitalon Review?

Labeling consistency matters because Epitalon has multiple naming variants. A listing may reference Epitalon, Epithalon, Epithalone, AEDG, or Ala-Glu-Asp-Gly; those labels should map back to the same compound identity record [1].

When a research team evaluates where to buy Epitalon for research, label consistency is part of risk reduction. It helps prevent confusion between synonyms, catalog fields, and batch documents.

Storage and Handling Documentation Review

Storage and handling documentation should be recorded as part of laboratory material management. If the product page identifies a lyophilized peptide, the supporting documentation should state the relevant storage conditions and recordkeeping expectations.

This section is documentation-focused. It does not provide setup, personal-use, or experimental application guidance.

Research Procurement Checklist for Epitalon Product Pages

A procurement checklist helps research buyers compare supplier documentation without drifting into consumer framing.

• Verify that the peptide is labeled for research-use-only positioning.
• Review the batch-specific certificate of analysis.
• Confirm that peptide purity is supported by analytical testing.
• Check that the lot number on the COA matches the product documentation.
• Compare compound name, synonym, molecular weight, and sequence across records [1], [2].
• Assess whether the product page avoids claim-led, clinical-use, and consumer-outcome framing.
• Document storage and handling language in a laboratory record.
• Separate published literature context from product-page claims.

Peptide quantification and purity review can vary by method, which is why method context should be read with the COA rather than reduced to a single number [21].

What Should Lab Teams Compare Before Procurement?

Lab teams should compare supplier documentation across identity, purity, method, lot, date, label, and storage records. They should also compare the product-page language against the RUO boundary.

For Epitalon, key identity cross-checks include the compound name, Epithalon spelling variant, AEDG sequence, molecular formula, and molecular weight [1].

Pure Lab Peptides Documentation Review Pathway

The pathway is: confirm RUO framing, review compound identity, compare COA and lot records, evaluate analytical testing, then interpret literature separately.

Next Steps for Research Documentation Review

Review the product-page documentation, COA details, and RUO labeling before evaluating this compound for laboratory research. For research teams comparing peptide suppliers, prioritize COA availability, transparent labeling, lot-level documentation, and analytical testing records.

FAQs

What does research use only mean for Epitalon?

Research use only means Epitalon is intended solely for laboratory research contexts. It also means published literature should be interpreted as research context, not as product-positioning language.

What should researchers consider before they buy Epitalon for research?

Researchers should consider documentation first before they buy Epitalon for research. Key review points include RUO labeling, peptide identity, a batch-specific COA, analytical testing records, lot traceability, and supplier documentation. A source quality filter can also help separate official databases, peer-reviewed literature, and analytical records from unsupported marketing language.

What is Epitalon AEDG in research documentation?

Epitalon AEDG is documented as a short peptide associated with the Ala-Glu-Asp-Gly sequence, so identity review should compare the name, synonym records, molecular data, and peptide sequence [1]. Research documentation should also check whether batch records align with the product label, COA, and analytical testing files.

What analytical details can support Epitalon peptide review?

Analytical details can support Epitalon peptide review by showing how identity and purity were evaluated. Researchers may review HPLC records, LC-MS data, a chromatogram, retention time notes, assay context, and reference standard alignment when available. These records are strongest when they connect clearly to the same lot and COA.

Researchers Cited in This Guide

The researchers listed below are cited for relevant published work. Their inclusion does not imply that they wrote, reviewed, or endorsed this guide or Pure Lab Peptides products.

Vladimir K. Khavinson

Author profile: RUDN Journal of Medicine Profile

Vladimir K. Khavinson is recognized for published work connected to short peptide research, Epitalon literature, telomerase markers, and gene expression models. His publications helped shape the broader scientific background for discussing Epitalon as a synthetic tetrapeptide within bioregulator peptide research. The selected publications below are especially relevant to the article’s discussion of peptide identity, telomere and telomerase literature, AEDG sequence context, and peptide regulation in laboratory research models.

Selected publications:

• A paper on Epithalon peptide and telomerase markers — Bulletin of Experimental Biology and Medicine, 2003. DOI: 10.1023/A:1025493705728. PMID: 12937682
• A Molecules article examining AEDG peptide, gene expression, and protein synthesis markers — Molecules, 2020. DOI: 10.3390/molecules25030609. PMID: 32019204

Vladimir N. Anisimov

Author profile: ORCID

Vladimir N. Anisimov’s peer-reviewed publications examine Epitalon in preclinical models, including carcinogenesis and other model-specific endpoints. The selected work provides context for evaluating experimental findings and their limitations.

Selected publications:

• A Biogerontology paper on Epitalon biomarkers and tumor-incidence model endpoints — Biogerontology, 2003. PMID: 14501183
• A Cancer Letters paper using an Epitalon preclinical carcinogenesis model — Cancer Letters, 2002. DOI: 10.1016/S0304-3835(02)00090-3. PMID: 12049808

REFERENCES

1. National Center for Biotechnology Information. Epitalon compound record. PubChem. Accessed 2026.
2. National Center for Advancing Translational Sciences. Epitalon substance record. Inxight Drugs. Accessed 2026.
3. Araj SK, et al. Overview of Epitalon—highly bioactive pineal tetrapeptide. International journal of molecular sciences. 2025. PMID: 40141333.
4. Khavinson VK, Bondarev IE, Butyugov AA, et al. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bulletin of Experimental Biology and Medicine. 2003. DOI: 10.1023/A:1025493705728. PMID: 12937682.
5. Al-Dulaimi S, Thomas R, Matta S, Roberts T. Epitalon and telomere length in human cell-line models. Biogerontology. 2025. DOI: 10.1007/s10522-025-10315-x. PMID: 40908429.
6. Lee J, Pellegrini MV. Biochemistry, Telomere and Telomerase. StatPearls, NCBI Bookshelf. Updated 2022.
7. de Lange T. How telomeres solve the end-protection problem. Science. 2009. PMID: 19965504.
8. Arendt J. Physiology of the Pineal Gland and Melatonin. Endotext, NCBI Bookshelf. 2022.
9. Khavinson V, Goncharova N, Lapin B. Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys. Neuro Endocrinology Letters. 2001. PMID: 11524632.
10. Khavinson V, Diomede F, Mironova E, et al. AEDG peptide research involving gene expression and protein synthesis. Molecules. 2020. DOI: 10.3390/molecules25030609. PMID: 32019204.
11. Kozina LS, et al. Antioxidant properties of pineal peptide preparations. Archives of Gerontology and Geriatrics. 2007. PMID: 17317455.
12. Anisimov VN, et al. Epitalon research involving lifespan markers and spontaneous tumor incidence in mice. Biogerontology. 2003. PMID: 14501183.
13. Anisimov VN, Khavinson VK, Popovich IG, Zabezhinski MA. Epitalon and chemically induced colon carcinogenesis model research. Cancer Letters. 2002. DOI: 10.1016/S0304-3835(02)00090-3. PMID: 12049808.
14. U.S. Food and Drug Administration. Analytical Procedures and Methods Validation for Drugs and Biologics. FDA Guidance. 2015; content current as of 2020.
15. U.S. Food and Drug Administration. Q2(R2) Validation of Analytical Procedures. FDA / ICH Guidance. 2024.
16. U.S. Food and Drug Administration. Q14 Analytical Procedure Development. FDA / ICH Guidance. 2024.
17. Mant CT, Hodges RS. HPLC analysis and purification of peptides. Methods in Molecular Biology. 2007. PMID: 18604941.
18. Karpievitch YV, Polpitiya AD, Anderson GA, Smith RD, Dabney AR. Liquid chromatography mass spectrometry-based proteomics. Annals of Applied Statistics. 2010. DOI: 10.1214/10-AOAS341. PMID: 21593992.
19. National Institute of Standards and Technology. Mass-to-Charge Ratio. NIST Glossary. 2023.
20. U.S. Food and Drug Administration. In Vitro Diagnostic Device Labeling Requirements. FDA. Content current as of 2023.
21. Li C, Bhavaraju S, Thibeault MP, et al. Survey of peptide quantification methods and comparison of reproducibility. Journal of Pharmaceutical and Biomedical Analysis. 2019. PMID: 30640042.

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Research Disclaimer

This material is supplied strictly for in vitro laboratory research and is not for human or veterinary use. Published studies describe specific experimental materials, models, and methods; they do not establish the safety, efficacy, or suitability of this catalog product for non-research use. Review the original publications and the lot-specific analytical documentation independently.