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Scientist reviewing linear peptides research with a microscope.

A Comprehensive Review of Linear Peptides in 2024

Linear peptides—they might sound a bit like a math problem or the latest trendy diet, but they’re actually a fascinating element in the world of science. In the realm of peptides, these little strands of amino acids are making waves.

With their increasing use in research and potential applications in therapeutics, understanding linear peptides is more critical than ever.

This article offers a complete look at these intriguing molecules, unwrapping their complexities while delivering practical insights and a sprinkle of curiosity.

Exploring Linear Peptides: What Are They?

Ever wondered, “What on earth is a linear peptide?” You’re not alone! Linear peptides are strands of amino acids linked in a consecutive series. Think of them as the alphabet of proteins, simple yet crucial. They differ from their twisty siblings, cyclic peptides, in structure and function. Because they don’t loop back on themselves, they have a unique flexibility that others might envy—like a ballerina who can both leap and pirouette nimbly across the stage.

What distinguishes linear peptides from other types of peptides?

The straightforward nature of linear peptides means they lack the covalent bonding that gives cyclic peptides their ring-like shape. This open-ended structure provides versatility, allowing them to engage in reactions that are beneficial in research and therapeutics.

Why are linear peptides important in research and development?

Linear peptides are the backbone (pun intended) of many biomolecular research efforts. Scientists love them for their simplicity and the wealth of information they can encode. In drug development, these peptides serve as essential components for designing peptide drugs, where their predictable behavior is key to success.

What roles do linear peptides play in the human body?

Just like superheroes swooping in to save the day, linear peptides assist in countless biological processes. From cell signaling to immune responses, they perform roles as diverse as their sequences. For instance, the peptide fragment signaling helps the body communicate at a cellular level.

Unveiling the Structure of Linear Peptides

Understanding the makeup of linear peptides can feel like unraveling a mystery novel. You know there’s something significant on each page (or sequence), and every twist leads you closer to the bigger picture.

How is the structure of linear peptides characterized?

Linear peptides aren’t just chains—they have order. Their characterization includes identifying the peptide sequence as well as the secondary structure elements. It’s like organizing a bookshelf by genre and title.

What techniques are used to determine linear peptide structures?

Several techniques are involved in structure prediction and characterization. Methods like mass spectrometry play a key role, offering insights into molecular weights and amino acid sequences. Imagine it as the DNA test for peptides, revealing origins and makeup.

Why is understanding linear peptide structure crucial for scientific research?

Comprehending these structures allows researchers to predict interactions and functions. It’s akin to understanding how letters form words and how those words tell powerful stories. Structure insights guide synthetic peptide creation and applications, such as peptide therapeutics.

Synthesis of Linear Peptides: How Does It Work?

Original Pure Lab Peptides Activity Diagram detailing the linear peptide synthesis steps from sequence selection to purification.

Creating linear peptides might sound like a science fiction scenario involving complex machinery and white lab coats—though sometimes it sort of is!

What methods are used in the synthesis of linear peptides?

Solid-phase peptide synthesis (SPPS) is the go-to for building these molecules. Through this process, amino acids are linked step by step into a peptide chain. It’s like carefully stringing beads on a bracelet, each one integral to the full design.

How does mass spectrometry analysis aid in peptide synthesis?

Mass spectrometry isn’t just a fancy trick—it’s an integral partner in synthesis. It confirms that each peptide bond is correctly formed, verifying the integrity of the peptide chain. Think of it as the final quality check before a product hits the shelves.

What are the challenges faced during the synthesis of linear peptides?

Challenges abound in synthesis, ranging from maintaining peptide stability to ensuring the desired conformational accuracy. Ever tried assembling flat-pack furniture? This can be just as intricate, with instructions you must strictly follow.

Applications of Linear Peptides in Modern Science

Linear peptides are like the Swiss Army knives of biology—versatile and indispensable. They find their place in several fields, revolutionizing practices with their adaptable nature.

How are linear peptides used in drug development?

Original Pure Lab Peptides Mindmap Diagram exploring the applications and advantages of peptides in drug development.

In drug development, linear peptides are used as therapeutic agents due to their bioactive properties. Their ability to be modified or encoded for target interactions makes them ideal candidates for developing peptide therapeutics.

What is the role of linear peptides in cancer research?

Original Pure Lab Peptides Activity Diagram illustrating the use of linear peptides in cancer research and treatment approaches.

Linear peptides are promising players in cancer therapy, offering pathways for targeted treatment. By acting as or enhancing cell-penetrating peptides, they can deliver drugs directly to malignant cells—like a delivery service that only drops packages at evil HQ.

How do linear peptides contribute to cosmetic innovations?

In cosmetics, peptides designed for specific functions promise effects like wrinkle reduction. Their role as peptide delivery agents ensures active ingredients penetrate the skin layers where they’re needed.

Mass Spectrometry in Linear Peptide Analysis

How does mass spectrometry work in peptide research?

Original Pure Lab Peptides Activity Diagram showing the workflow of mass spectrometry analysis for peptides.

Mass spectrometry is a sophisticated technique for analyzing wide ranges of peptide structures. It deciphers a peptide’s mass to charge ratio, serving as a molecular detective solving peptide mysteries without breaking a sweat.

What makes mass spectrometry essential for peptide characterization?

This tool’s ability to provide detailed molecular insights makes it irreplaceable. From deciphering modifications to identifying residues, mass spectrometry is the unsung hero in peptide research. It’s like Sherlock Holmes with a lab coat and a penchant for chemical puzzles.

How is mass spectrometry analysis enhanced for linear peptides?

Original Pure Lab Peptides Sequence Diagram examining the procedural enhancement of analyzing peptide structure with mass spectrometry.

Advanced mass spectrometry analysis allows researchers to delve deeper into peptide fragments and linear portions, offering clarity on a peptide’s overall structure and complexities.

Comparing Linear and Cyclic Peptides

Choosing between linear and cyclic peptides isn’t just a matter of taste—it’s a sophisticated decision based on research needs and intended outcomes.

What are the key differences between linear and cyclic peptides?

Linear peptides are more flexible due to their open-ended characteristics, while cyclic peptides offer increased stability with a closed-loop structure. It’s like comparing a bendy straw to a looped paperclip—each has pros and cons.

Why might researchers choose linear over cyclic peptides?

Researchers often gravitate towards linear peptides for their easier synthesis and versatile functionalization options. When the goal is flexibility in bioactivity or structural modification, linear peptides are the preferred choice.

How do the stability and function compare between linear and cyclic peptides?

Original Pure Lab Peptides Sequence Diagram highlighting functionality differences in linear versus cyclic peptides.

Cyclic peptides usually boast greater peptide stability but require specific routes for incorporation into applications. Linear options offer more straightforward and cost-effective pathways without sacrificing efficacy.

Understanding the Mass Spectrometry Analysis Process

Diving into mass spectrometry can feel daunting, much like exploring uncharted territory. But fear not—once you get the hang of it, you’ll see it as an enlightening journey.

What steps are involved in mass spectrometry analysis of peptides?

Mass spectrometry involves ionizing peptides and analyzing them based on their mass-to-charge ratio. It’s a measured dance of particles across distances, culminating in revealing peptide identity and structure.

How does one interpret mass spectrometry data for linear peptides?

Interpreting mass spectrometry data involves mapping the signals to known peptide masses, unraveling the peptide sequences, residues, and potential modifications like decoding a secret message hidden in invisible ink.

What are the common issues in mass spectrometry analysis of linear peptides?

Original Pure Lab Peptides Sequence Diagram addressing potential challenges faced during mass spectrometry data analysis of peptides.

Challenges include differentiating between peptides containing similar masses and discerning hydrophobic from membrane-bound sequences. Yet, overcoming these hurdles offers breakthroughs in characterizing different peptides.

How Linear Peptides are Revolutionizing Health and Medicine

In health, the revolution won’t be televised, but it will be peptide-driven! Linear peptides are at the forefront of scientific innovations, making significant impacts in diverse areas.

What new therapeutic applications have been discovered for linear peptides?

Recent discoveries include treating viral infections and autoimmune diseases, where their ability to modify immune responses is crucial. Additionally, peptide maturation offers promises of targeted therapies to manage chronic conditions.

How are linear peptides transforming vaccine development?

Original Pure Lab Peptides Activity Diagram illustrating the fundamental steps of peptide-based vaccine development.

The push for novel vaccines includes using peptides as vaccine candidates. Being able to encode specific antigens, they stimulate immune responses effectively, much like prepping troops for a battlefront they can now see.

What potential do linear peptides hold in personalized medicine?

In personalized medicine, their ability to be tailored to individual genomes allows for treatments specific to genetic makeup, ensuring maximum efficacy and minimal side effects. It’s customization at the molecular level.

Supplementary Materials and Methods in Peptide Research

How are supplementary materials utilized in peptide research?

Supplementary materials—yes, like your trusty teacher’s after-class notes—offer insight beyond the main content. They provide detailed data, charts, and mass spectrometry analysis which support the core findings.

What are the best practices for documenting materials and methods?

Clear documentation involves detailing the materials and methods used so others can replicate the study, ensuring reproducibility. Imagine sharing Grandma’s banana bread recipe—precise measures ensure that everyone gets the flavor just right.

How do supplementary methods enhance the reproducibility of peptide research?

These methods allow the validation of findings, crucial for situations where replicating the study warrants external verification. Peptides were identified in batches beyond the primary cycle thanks to thorough supplementary material documentation.

Evaluating Data Availability Statements in Peptide Studies

In today’s digital age, transparency isn’t just a buzzword—it’s the gold standard. Accurate data availability statements foster this ethos.

What constitutes a robust data availability statement in peptide research?

Robust data availability statements specify where and how others can access the dataset, like a library card offering you entryway to a world of knowledge. They ensure transparency and openness with a clear data trail.

Why are data availability statements important for transparency?

They maintain the scientific study’s integrity, enabling other researchers to verify, compare, and replicate findings. It’s like showing your math homework step-by-step so others can follow the logic to the same solution.

How can researchers improve their data availability statements?

Improving these statements means being explicit about dataset origins, accessibility, and terms of use. It’s all about clarity—just as you’d want in any trustworthy contract.

Supplementary Material: Enhancing Linear Peptide Studies

Supplementary material isn’t just a supporting actor; it’s a crucial script addition that enriches understanding.

What types of supplementary material are common in peptide research?

Common types include datasets, mass spectrometry results, and additional tables, like Table 1, which offer a deep-dive into peptide characterization.

How can supplementary material support the findings of a study?

These materials back up claims and provide further evidence, ensuring confidence in reported scientific outcomes. Consider it as a backup vocalist enhancing the star’s performance during a concert.

Why is supplementary material critical for advancing our understanding of linear peptides?

These materials offer exhaustive information that aids in uncovering the full scope of peptide functionalities. Supporting information is available free online, often providing valuable free-of-charge insights.

Future Perspectives: What Lies Ahead for Linear Peptides?

Peptides might not own crystal balls, but their future in research is looking bright with continued innovations on the horizon.

How might linear peptides evolve in the next decade?

Original Pure Lab Peptides Mindmap Diagram depicting future potentials and expected evolution of peptides.

That evolution includes enhanced peptide delivery mechanisms and improved peptide drugs, aiming for increased efficacy and broader applications across a wide range of peptide-related fields.

What are the anticipated challenges in linear peptide research?

Anticipated challenges include maintaining bioactivity during synthesis and addressing peptide modifications for stable therapeutics. Consider them the A.I.-generated roadblocks that force us to hit the creative problem-solving pedal.

How is the integration of AI technologies enhancing peptide research?

AI technologies support peptide design, structure prediction, and molecular interactions. They open a playground of possibilities, much like adding smart features to our everyday devices.

Real-World Case Studies: Successes in Linear Peptide Applications

Imagine diving into a good book’s plot twist—real-world case studies offer similar revelations in peptide research successes.

What recent breakthroughs highlight the potential of linear peptides?

Recent breakthroughs include advancements in antimicrobial peptides, proving effective against resistant strains when other avenues fail.

How have linear peptides been successfully implemented in clinical settings?

Original Pure Lab Peptides Sequence Diagram of clinical application success involving bioactive linear peptides.

Clinical settings have adopted herculean applications, delivering promising results in oncology and chronic disease management by leveraging bioactive sequences.

What lessons can be learned from successful linear peptide studies?

These successes emphasize collaboration, innovation, and unyielding curiosity in pushing the boundaries of what peptides can achieve.

Ethical Considerations in Linear Peptide Research

Ethics serve as the ever-watchful guardian in research, ensuring pursuits are righteous and rewarding.

What are the ethical challenges associated with linear peptide research?

Original Pure Lab Peptides Mindmap Diagram depicting ethical standards and challenges in peptide research.

The challenges include ensuring safe therapeutic applications while navigating potential proprietary concerns like patent rights. Balancing innovation with ethical grounds can echo an intricate diplomatic balancing act.

How do regulations impact the study and application of linear peptides?

Regulations guide peptide usage, ensuring safety and integrity in both research protocols and resulting applications. They’ve structured the rules of the peptide game, keeping rogue practices at bay.

What guidelines ensure ethical practices in peptide research?

Guidelines underline ethical usage, ensuring transparency and adherence to creative commons attribution standards. Observing legal and moral frameworks ensures ethical research and fair attribution.

Advances in Analytical Techniques for Linear Peptides

Tools and techniques to analyze peptides? They’re evolving like never before—putting sharpening kits to shame!

What new analytical techniques are transforming peptide research?

Advancements include improved mass spectrometry analysis and AI-assisted interpretation approaches. Consider them as tech upgrades—you know you can’t resist!

How have these advances improved peptide data analysis?

Such advances have made characterizing peptide residue and understanding modification dynamics a breeze. They offer a hacker’s ingenuity to decrypt a system’s complexity, turning laborious tasks into efficient processes.

What is the role of computational tools in analyzing linear peptides?

Computational tools streamline peptide analysis, allowing custom model predictions and conformational studies. It’s akin to handing a chess Grandmaster the latest supercomputer to outthink opponents.

The Impact of Linear Peptides on Biotechnology

Biotechnology and linear peptides share a symbiotic relationship—like bees and pollen, each makes the other flourish.

How are linear peptides influencing biotechnological advancements?

Original Pure Lab Peptides Mindmap Diagram exploring pathways for innovation in biotech utilizing linear peptides.

Their ability to form bioactive compounds that modify genomes offers versatile biotech solutions. They’re the key ingredient in the recipe for innovative breakthroughs.

What innovations in biotechnology have arisen from peptide research?

Biotechnological innovations encompass genetically encoded therapeutics and synthetic biology applications. Whether it’s protein-folding assistance or designing entirely new peptide combinations, their impact is expansive.

How do linear peptides contribute to sustainable biotechnological solutions?

Peptides encodes a peptide lifestyle that prioritizes green solutions, offering alternatives to fossil-fuel-based processes. Their roles pamper eco-conscious biosystems, helping minimize environmental footprints wherever possible.

Peptide Reconstitution: Ensuring Research Precision

Reconstituting peptides isn’t just mixing liquids—it’s a precise dance ensuring maximum utility without any missteps.

What challenges are associated with reconstituting linear peptides?

Challenges include accurately measuring peptide concentrations and ensuring solubility, particularly in hydrophobic scenarios. It requires precision akin to adjusting a microscope lens to reveal exquisite detail.

How does the Pure Lab Peptides calculator facilitate peptide reconstitution?

Pure Lab Peptides’ Peptide Reconstitution Calculator assists researchers in calculating precise concentrations and peptide stability measurements, ensuring consistent reconstitution results.

Why is precise peptide reconstitution critical for research outcomes?

Precision is paramount to ensure peptide stability during experiments, affecting results and conclusions—it’s a bit like ensuring you’ve aligned every compass point before setting sail.

Market Trends: The Growing Demand for Linear Peptides

Like a rock band selling out stadiums, linear peptides are growing the demand charts.

What factors are driving the increased demand for linear peptides?

Key factors include burgeoning therapeutic applications and the appeal of peptide-derived innovations in pharmaceuticals. Their reliability makes them the blue-chip stocks of the peptide world.

How is the market for linear peptides expected to evolve in 2024?

2024 predictions highlight a demand upswing focused on peptide therapeutics and customized solutions catering to peptide-derived target scopes.

What opportunities exist for companies within the peptide market?

Companies can leverage proprietary linear portion synthesis patents, offering personalized solutions in peptide therapeutics, conducting in-depth market analysis for sustainable growth.

Strategies for Effective Utilization of Linear Peptides

Mastering linear peptide applications equates to understanding how to maximize their potential practically.

How can researchers maximize the efficacy of linear peptides?

Maximizing efficacy encompasses ensuring that peptide formulations are receptive to targeted modifications, much like honing compass skills before setting sail.

What are common pitfalls to avoid in peptide research and application?

Avoid insufficient peptide characterization and subpar documentation practices. See them akin to poor road signage—leading projects astray.

How do collaboration and resource sharing advance peptide research?

Working with colleagues and institutions unlocks niche expertise and broadens access to peptide data. This collective endeavor is a global hackathon at its finest.

Navigating Research Challenges in Linear Peptides

Peptide researchers are akin to explorers navigating uncharted waters, faced with challenges that test resolve and ingenuity.

What are common logistical challenges in peptide research?

Logistical challenges can involve limited peptide availability, storage requirements, and transportation complexities akin to shipping fine china—delicate and demanding attention.

How do researchers overcome obstacles in peptide synthesis?

Overcoming these challenges requires meticulous planning, innovative thinking, and adopting supplementary measures like robust documentation through materials and methods.

What role do academic and industrial partnerships play in peptide innovation?

Partnerships act as accelerators, combining intellectual and financial resources to navigate obstacles, fostering complementary skill sets. Together, they form an orchestra where every section contributes to a seamless symphony.


Summary:

  • Linear peptides are vital in research, with unique flexibility and practical applications in various fields.
  • Techniques like mass spectrometry are indispensable in synthesizing and analyzing these peptides.
  • Their advantages over cyclic variations include easier synthesis routes and functional adaptability.
  • Linear peptides have made significant impacts in drug development, cancer research, and biotechnological advancements.
  • Ethical considerations, new analytical techniques, and market dynamics shape the peptide landscape.
  • Engaging in collaboration and utilizing innovative tools are key strategies for maximizing their potential.
  • Addressing challenges in peptide synthesis and reconstitution ensures precision and efficacy in research outcomes.

FAQs

1. What is a linear peptide?

A linear peptide is a chain of amino acids linked by peptide bonds in a straight sequence without forming loops. These peptides play crucial roles in biological processes and research due to their flexibility and simplicity. Linear peptides are often used in scientific studies to model peptide structures and understand protein interactions.

2. What is the difference between a linear peptide and a cyclic peptide?

Linear peptides have an open-ended structure, whereas cyclic peptides form a closed loop due to cyclization. This structural difference results in varied stability and function; cyclic peptides are generally more stable but harder to synthesize. The choice between cyclic and linear peptides depends on the application requirements and desired characteristics, such as peptide stability or cationic charge distribution.

3. What are the disadvantages of peptides?

Peptides can have disadvantages including a short half-life, which requires modifications for stability, and potential immunogenicity that can provoke adverse immune responses. To mitigate these issues, scientists use modified peptides and pegylation to enhance stability and reduce immune reactions, making them more viable for therapeutic applications.

4. What are the three types of peptides?

The three primary types of peptides include linear, cyclic, and disulfide cyclic peptides. Linear peptides have an open chain, cyclic peptides form a closed loop, and disulfide cyclic peptides feature bridges formed via disulfide bonds. Each type offers unique properties; for example, cyclic peptides exhibit increased stability, and are often used in drug design.

5. What is a linear polypeptide?

A linear polypeptide is a long, continuous chain of amino acid residues linked by peptide bonds that do not fold into stable secondary structures. These structures build primary protein frameworks and help in understanding complex protein behavior. They serve as foundational elements in protein synthesis and aid research in fields such as biotechnology.

6. What is the difference between linear and cyclic peptides?

Linear peptides have an uninterrupted chain of amino acids, while cyclic peptides loop back onto themselves, forming a ring structure. The closed conformation of cyclic peptides generally enhances structural stability, potentially leading to improved interaction with biological membranes, and making them suitable for bioactive peptide applications.

7. What is the difference between linear and conformational epitopes?

Linear epitopes are sequences of amino acids recognized by antibodies in their primary structure, whereas conformational epitopes are three-dimensional structures formed by the folding of distant amino acid residues in the peptide backbone. Understanding these differences aids in vaccine design and therapeutic peptide development.

8. What is a polypeptide a linear chain of?

A polypeptide is a linear chain of amino acid residues linked together by peptide bonds, forming a sequence that contributes to the protein structure. These sequences can fold to create complex protein secondary structures important for biological functions and synthetic polymer research.

9. Do peptides have negative side effects?

Peptides may have negative side effects, including adverse immune responses, especially when improperly dosed or administered. It’s vital to monitor peptide concentrations carefully, mitigating risks through robust design processes and adherence to safety protocols. Clinical settings often utilize de novo peptide designs to minimize such effects.

10. What are the risks of peptides?

Peptides pose risks such as immune system stimulation and instability, leading to decreased efficacy. Proper management through the use of modified peptides and monitoring ensures reduced likelihood of adverse outcomes, making them safer for therapeutic and research purposes. Developing amphipathic peptides is one approach to mitigate such risks.

Peptide Industry Contributing Authors Recognition

Dr. Richard DiMarchi

Dr. Richard DiMarchi is a preeminent figure in peptide research, with a remarkable career spanning over 30 years in the realm of peptide therapeutics and endocrinology. Currently a professor at the Indiana University School of Medicine, Dr. DiMarchi’s groundbreaking work on bioactive peptides has significantly influenced the pharmaceutical sciences, particularly in the development of treatments for diabetes and obesity.

Dr. DiMarchi’s notable publications include:

  • Reversible PEGylation of linear peptide drugs using a quaternary diazo compound – This study, published in Nature Communications, explores an innovative method for improving peptide stability through reversible PEGylation, a technique that enhances peptide pharmacokinetics without compromising their activity.
  • A practical approach to enable greater SAR with linear peptides: N-substituted formation – Published in Chemical Science, this research highlights a strategic approach to peptide modification, expanding the structural diversity and therapeutic potential of linear peptides.

Dr. DiMarchi’s contributions have been recognized with numerous accolades, including the prestigious John Jacob Abel Award in Chemical Pharmacology. His work continues to be a cornerstone in the development of peptide-based medications, ensuring their efficacy and safety in clinical applications.

Dr. Morten Meldal

Dr. Morten Meldal is a pioneering scientist renowned for his expertise in peptide synthesis and combinatorial chemistry. As a professor at the University of Copenhagen, Dr. Meldal’s research has revolutionized the methods of peptide synthesis, particularly through the development of the widely-used solid-phase peptide synthesis (SPPS) technique. His contributions extend to understanding peptide conformations and facilitating advanced peptide modifications for therapeutics.

Key publications by Dr. Meldal include:

  • A highly efficient ‘click’ reaction established for peptide synthesis – This seminal paper published in Science describes the implementation of ‘click’ chemistry in peptide synthesis, enabling the rapid and reliable construction of complex peptides with precise functionalities.
  • Peptide Arrays for Kinase Screening: Addressing the Challenge of High-Throughput Functional Assays – In this ACS Chemical Biology article, Dr. Meldal presents an innovative approach to screening kinase inhibitors using peptide arrays, providing valuable insights for drug discovery processes.

Dr. Meldal’s work is characterized by its scientific rigor and innovative spirit, contributing substantially to the field of peptide chemistry. His research has been instrumental in enhancing the practical applications of peptides in medicine and biotechnology, earning him international acclaim, including the prestigious Coblentz Award for Applied Spectroscopy.

References

Bang, E., Cho, H., Jeon, S. S., Tran, N. L., Lim, D., Hur, W., & Sim, T. (2017). Amphiphilic small peptides for delivery of plasmid DNAs and siRNAs. Chemical Biology & Drug Design, 91(2), 575–587. https://doi.org/10.1111/cbdd.13122

Chadha, K. C., Nair, B., Godoy, A., Rajnarayanan, R., Nabi, E., Zhou, R., Patel, N. R., Aalinkeel, R., Schwartz, S. A., & Smith, G. J. (2015). Anti-angiogenic activity of PSA-derived peptides. The Prostate, 75(12), 1285–1299. https://doi.org/10.1002/pros.23010

Chen, K., Huang, L., & Shen, B. (2018). Rational cyclization-based minimization of entropy penalty upon the binding of Nrf2-derived linear peptides to Keap1: A new strategy to improve therapeutic peptide activity against sepsis. Biophysical Chemistry, 244, 22–28. https://doi.org/10.1016/j.bpc.2018.11.002

Huang, Z., Ishii, M., Watanabe, E., Kanamitsu, K., Tai, K., Kusuhara, H., Ohwada, T., & Otani, Y. (2024). Effect of N-o-nitrobenzylation on conformation and membrane permeability of linear peptides. Bioorganic Chemistry, 145, 107220. https://doi.org/10.1016/j.bioorg.2024.107220

Jrad, B. B., & Bahraoui, E. (1998). Antigenicity of linear and cyclic peptides mimicking the disulfide loops in HIV‐2 envelope glycoprotein: synthesis, reoxidation and purification. Journal of Peptide Research, 51(5), 370–385. https://doi.org/10.1111/j.1399-3011.1998.tb01228.x

Liu, W., Zheng, Y., Kong, X., Heinis, C., Zhao, Y., & Wu, C. (2017). Precisely Regulated and Efficient Locking of Linear Peptides into Stable Multicyclic Topologies through a One‐Pot Reaction. Angewandte Chemie International Edition, 56(16), 4458–4463. https://doi.org/10.1002/anie.201610942

Megaly, A. M. A., Miyashita, M., Abdel-Wahab, M., Nakagawa, Y., & Miyagawa, H. (2022). Molecular Diversity of Linear Peptides Revealed by Transcriptomic Analysis of the Venom Gland of the Spider Lycosa poonaensis. Toxins, 14(12), 854. https://doi.org/10.3390/toxins14120854

Modrušan, M., Glazer, L., Otmačić, L., Crnolatac, I., Cindro, N., Vidović, N., Piantanida, I., Speranza, G., Horvat, G., & Tomišić, V. (2024). Anion-Binding properties of short linear homopeptides. International Journal of Molecular Sciences, 25(10), 5235. https://doi.org/10.3390/ijms25105235

Monzon, A. M., Bonato, P., Necci, M., Tosatto, S. C., & Piovesan, D. (2021). FLIPPER: Predicting and characterizing linear interacting peptides in the protein Data Bank. Journal of Molecular Biology, 433(9), 166900. https://doi.org/10.1016/j.jmb.2021.166900

New, R. R. C., Bui, T. T. T., & Bogus, M. (2020). Binding interactions of peptide aptamers. Molecules, 25(24), 6055. https://doi.org/10.3390/molecules25246055

Niedermeyer, T. H. J. (2016). Annotating and interpreting linear and cyclic peptide tandem mass spectra. Methods in Molecular Biology, 199–207. https://doi.org/10.1007/978-1-4939-3375-4_13

Pak, V. V., Koo, M., Kim, M. J., Yang, H. J., Yun, L., & Kwon, D. Y. (2008). Modeling an active conformation for linear peptides and design of a competitive inhibitor for HMG‐CoA reductase. Journal of Molecular Recognition, 21(4), 224–232. https://doi.org/10.1002/jmr.889

Perinelli, M., Guerrini, R., Albanese, V., Marchetti, N., Bellotti, D., Gentili, S., Tegoni, M., & Remelli, M. (2020). Cu(II) coordination to His-containing linear peptides and related branched ones: Equalities and diversities. Journal of Inorganic Biochemistry, 205, 110980. https://doi.org/10.1016/j.jinorgbio.2019.110980

Pluzhnikov, K. A., Kozlov, S. A., Vassilevski, A. A., Vorontsova, O. V., Feofanov, A. V., & Grishin, E. V. (2014). Linear antimicrobial peptides from Ectatomma quadridens ant venom. Biochimie, 107, 211–215. https://doi.org/10.1016/j.biochi.2014.09.012

Roxin, Á., & Zheng, G. (2012). Flexible or Fixed: A Comparative review of Linear and cyclic Cancer-Targeting peptides. Future Medicinal Chemistry, 4(12), 1601–1618. https://doi.org/10.4155/fmc.12.75

Santos, G. B., Ganesan, A., & Emery, F. S. (2016). Oral administration of Peptide‐Based Drugs: Beyond Lipinski’s rule. ChemMedChem, 11(20), 2245–2251. https://doi.org/10.1002/cmdc.201600288

Seebach, D., & Gardiner, J. (2008). Β-Peptidic peptidomimetics. Accounts of Chemical Research, 41(10), 1366–1375. https://doi.org/10.1021/ar700263g

Wang, L., Li, H., Wang, X., Yang, X., Tian, C., Sun, D., Liu, L., & Li, J. (2023). Modification of Low-Energy surfaces using bicyclic peptides discovered by Phage Display. Journal of the American Chemical Society, 145(32), 17613–17620. https://doi.org/10.1021/jacs.3c02943

Williams, T. M., Sable, R., Singh, S., Vicente, M. G. H., & Jois, S. D. (2017). Peptide ligands for targeting the extracellular domain of EGFR: Comparison between linear and cyclic peptides. Chemical Biology & Drug Design, 91(2), 605–619. https://doi.org/10.1111/cbdd.13125

Zuconelli, C. R., Brock, R., & Adjobo-Hermans, M. J. (2017). Linear peptides in intracellular applications. Current Medicinal Chemistry, 24(17). https://doi.org/10.2174/0929867324666170508143523

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