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Research Use Notice

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Product Documentation

Details, specifications, and reviews

Description

IGF-1 LR3 1 mg

Buy IGF-1 LR3 1 mg for laboratory research, supplied as lyophilized powder in one boxed 3 mL vial.

IGF-1 LR3 is a modified insulin-like growth factor used in laboratory research on growth-factor interactions and analytical identification.

What distinguishes the LR3 analog?

The reference Long Arg3-IGF-I structure has an extension of 13 amino acids at the N-terminus and an arginine substitution at position 3 of the IGF-I portion. These changes distinguish it from native IGF-I, R3-IGF-I without the extension, and the truncated DES(1-3) analog. Keep the complete analog name in the method and purchase record.

In Francis and colleagues’ original comparison, the modified proteins interacted differently with IGF-binding proteins. Long Arg3-IGF-I produced stronger responses than native IGF-I in some cell models, while the comparison reversed in fibroblasts that lacked detectable secreted binding proteins. That distinction matters when selecting a reagent: activity depends on the experimental system, not simply the presence of the LR3 name.

Analytical identity and sample condition

Mongongu and colleagues used antibody-based purification followed by nano-liquid chromatography and high-resolution mass spectrometry to distinguish IGF-I analogs. Their work evaluated recovery and matrix effects in fortified serum and identified oxidized forms and N-terminal degradation products.

These observations show why an intact target, related forms and the sample matrix can all matter in analytical method development. They describe the preparations in that study; they do not establish the identity or activity of a separate commercial lot.

Review the material records

Use Documents for the available product files and review the applicable batch report alongside the vial label. Identity, chromatographic purity, measured content and biological activity answer different questions. Check which measurements a report actually contains before using it to support a method.

The labeled 1 mg amount is a material quantity, not a solution concentration. The 3 mL vial specifies the container capacity. Match the supplied form and material-specific handling guidance to your laboratory’s preparation and storage conditions. Current price and availability remain in the purchase section.

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