Pinealon 20mg

Researchers evaluating where to buy Pinealon for research should begin with compound identity, RUO labeling, COA availability, and batch-specific analytical documentation. Pinealon is discussed in published literature as Glu-Asp-Arg, a short synthetic tripeptide listed by PubChem as C15H26N6O8 with a computed molecular weight of 418.40 g/mol [1]. Published findings provide laboratory research context, not evidence of outcomes for a supplied product.

• Pinealon is a synthetic tripeptide also described as the EDR peptide, with Glu-Asp-Arg representing glutamic acid, aspartic acid, and arginine in sequence [1], [14].
• Published Pinealon research includes gene expression, protein synthesis, DNA interaction, oxidative stress, reactive oxygen species, and cell signaling contexts, but findings remain model-specific [2], [3], [5].
• Research buyers should review RUO labeling, product identity, batch-specific COA documentation, lot traceability, and storage documentation before procurement [21], [22].
• HPLC can support peptide purity review, while LC-MS and mass spectrometry can support peptide identity review when paired with suitable documentation [15], [16], [17].
• Published Pinealon research does not establish performance or suitability of a supplied research-only product.
• Catalog terms such as Pinealon 20mg describe the listing format; confirm the listed amount and compound identity against the batch documents.

Fast Answer: What Should Researchers Check Before They Buy Pinealon for Research?

Before buying Pinealon for laboratory research, review the compound name, RUO label, batch-specific COA, HPLC purity data, LC-MS or mass-spectrometry identity support, lot number, and storage documentation [15], [16], [18], [22]. Products discussed in this article are intended for laboratory research use only and are not intended for human or animal consumption.

What Documentation Should Come First

The first documentation layer is the product identity record: compound name, sequence, molecular formula, and listing information. PubChem identifies Glu-Asp-Arg as a tripeptide composed of L-glutamic acid, L-aspartic acid, and L-arginine joined by peptide linkages [1].

The second layer is batch-specific evidence. A certificate of analysis should connect the product listing to a lot number, purity method, identity method, date, and laboratory record where available. ISO Guide 31 describes reference-material documentation as a way to accompany materials with clear information that helps users confirm suitability for a defined purpose [23].

Why RUO Labeling Matters Before Procurement

RUO labeling identifies the intended laboratory research scope. FDA guidance describes RUO and investigational labeling in the context of products intended for research or investigation rather than established diagnostic positioning [21].

The eCFR also emphasizes labeling statements, lot or control numbers, purity and quality statements, and storage instructions for certain laboratory reagent contexts [22]. Review these documentation categories when evaluating a research material.

What Is Pinealon in Research Literature?

Pinealon is described in research literature as Glu-Asp-Arg, also known as EDR peptide [1], [2].

The literature includes molecular modeling, DNA interaction, gene expression, oxidative stress, and preclinical model discussions [2], [4], [5].

Compound Identity and Peptide Classification

PubChem lists Glu-Asp-Arg with molecular formula C15H26N6O8 and computed molecular weight 418.40 g/mol [1]. That identity record is useful for checking whether product-page documentation, COA information, and analytical records describe the same compound.

Pinealon peptide documentation should also distinguish compound identity from literature interpretation. A compound identity statement can be factual; a claim about what a product does is a different category and requires strict RUO boundaries.

Glu-Asp-Arg Sequence Context for Pinealon

Glu-Asp-Arg means glutamic acid, aspartic acid, and arginine in sequence. IUPAC amino acid nomenclature lists Glu for glutamic acid, Asp for aspartic acid, and Arg for arginine [14].

This sequence context matters because a short peptide can be described by both its name and residue order. For Pinealon, the EDR peptide naming convention helps connect the product-page record to literature that may use either Pinealon or Glu-Asp-Arg.

Why Synthetic Tripeptide Identity Matters

Synthetic tripeptide identity matters because purity alone does not prove identity. HPLC can separate and quantify peptide-related peaks, but mass spectrometry can add mass-based evidence that supports identity review [15], [16].

For research procurement, Pinealon identity should be checked across product-page text, COA documentation, and analytical testing records. The same compound name and sequence should appear consistently.

Pinealon Peptide Bioregulator Background

Pinealon peptide bioregulator research sits within a broader literature area on ultrashort peptides and gene expression. Reviews of peptide regulation describe short peptides as a class studied for interactions with gene expression and protein synthesis pathways [10], [12].

Khavinson Literature and Short Peptide Research

Khavinson literature has examined short peptides, including EDR, in relation to molecular genetics, gene expression, and protein synthesis [2], [10]. The EDR peptide review discusses Pinealon in the context of gene expression models and protein synthesis regulation [2].

How Pineal Gland Literature Informs Research Context

The term Pinealon can invite confusion because neighboring bioregulator literature may discuss the pineal gland. For Pinealon documentation, the primary identity anchor remains Glu-Asp-Arg rather than a tissue-origin assumption [1], [2].

Pineal gland literature provides background within broader bioregulator research, including Khavinson-group short-peptide publications.

Cellular and Gene Expression Research Context

Published Pinealon research includes cellular and gene expression themes. The EDR peptide review analyzes gene expression and protein synthesis regulation in molecular research context [2].

Gene expression itself is a broad biological process involving transcriptional control and interactions between regulatory factors and DNA regions [27].

What Gene Expression Models Can Examine

Gene expression models can examine changes in transcription, promoter-associated activity, protein synthesis markers, or pathway-linked signals under defined experimental conditions [2], [10], [27]. In Pinealon research, EDR has been discussed in relation to DNA interaction and gene-expression regulation [2], [4].

These studies address gene-expression questions in controlled laboratory models; their findings remain specific to those conditions.

Cellular Stress Response Models

Cellular stress response models can include oxidative stress, programmed cell death markers, cell signaling shifts, or protein expression changes. A Pinealon study reported EDR-related observations in cerebellar granule cells, neutrophils, and PC12 cell models under oxidative stress conditions [5].

These findings are model-specific evidence and do not establish outcomes for the supplied product.

Oxidative Stress and Reactive Oxygen Species Context

Reactive oxygen species appear in Pinealon literature through oxidative stress cell-model work [5]. In the same study, the authors reported changes in ROS accumulation and ERK 1/2 timing in specific cell models [5].

Pathway Research for Pinealon in Laboratory Research

Pinealon pathway research includes gene expression, DNA interaction, cell signaling, and oxidative-stress models. These are distinct categories of published research.

A pathway map can show where EDR peptide appears in the literature: DNA interaction, transcription-related models, protein synthesis, ERK signaling, and cellular stress. That map should include limitations, because pathway relevance is not the same as a product claim.

MAPK, ERK, and Cell Signaling Context

The Pinealon oxidative stress study reported delayed ERK 1/2 activation timing in its cell-model system [5]. ERK 1/2 is part of the broader MAPK/ERK pathway, a cell signaling lane often discussed in cellular stress response research [5].

These observations inform interpretation of cellular stress models; they do not establish outcomes for a supplied product.

Limits of Pathway Evidence

A pathway connection shows what a study examined. It does not show that a research material has a defined outcome outside the study setting.

What Cell Models Add to Research Applications

Cell models add controlled research applications because they let researchers examine defined molecular markers under defined assay conditions. For Pinealon, in vitro research has included cell models and DNA-interaction studies [3], [5].

Cell-model data can support research hypotheses and source discovery. It cannot replace analytical identity documentation, lot traceability, or RUO labeling on a product page.

Published Pinealon Research and Literature Interpretation

Published Pinealon research should be read through an evidence landscape, not as a single claim set. The safest framework separates in vitro findings, preclinical literature, review articles, analytical documentation, and RUO boundaries.

How Preclinical Findings Should Be Read

Preclinical findings should be read as model-specific literature. The Pinealon literature includes preclinical settings such as prenatal hyperhomocysteinemia and NMDA receptor subunit gene-expression research [6], [7].

These findings support literature review and evidence mapping, not direct use of a research-only product outside its intended scope.

What In Vitro Data Can and Cannot Support

In vitro data can support mechanistic questions about cell models, DNA interaction, signaling, and stress response markers. Fedoreyeva and colleagues reported short fluorescence-labeled peptides, including Pinealon, in cellular and nuclear compartments in a HeLa model and described interactions with nucleic acid structures [3].

That does not make the product a validated tool for every research setting. It means that in vitro literature can inform research context when interpreted narrowly.

Where Animal Model Literature Requires Caution

Animal model literature requires caution because it reflects a controlled study context. Pinealon research includes animal model literature, including rat offspring from prenatal hyperhomocysteinemia and older rat stress-model literature involving Cortexin and Pinealon [6], [8].

Related Pinealon Research

Related Pinealon literature uses the names EDR peptide and Glu-Asp-Arg and covers short peptides, peptide bioregulators, Cortexin and Pinealon, gene expression, DNA interaction, oxidative stress, and cell signaling.

Cortexin and Pinealon in Literature Mapping

The EDR peptide review identifies Pinealon in relation to Cortexin-derived peptide literature [2]. Separate literature also discusses Cortexin and Pinealon in older rat stress-model research [8].

These related publications can help researchers locate additional studies, but they do not support comparisons of supplied-product outcomes.

Hypoxia Models in Peptide Research Context

Published work on hypoxia with Cortexin and Pinealon concerns a specific preclinical model [8]. It provides context for Pinealon studies involving stress models and neurobiology.

When evaluating a paper, check peer-review status, the model description, measured endpoints, and limitations. Those details determine how narrowly the findings can be interpreted.

Rat Offspring Literature and Research Limits

Rat offspring literature appears in Pinealon’s published evidence base through prenatal hyperhomocysteinemia research [6]. It is useful for understanding how the compound has appeared in preclinical research models.

Preclinical findings remain specific to their study conditions and do not provide direct use guidance for a research-only material.

How Research Literature Stays Separate From Product Claims

Research literature and product claims are different categories.

Research-Only Labeling and Evidence Limits

FDA RUO guidance emphasizes that RUO labeling should be consistent with the product’s research-only positioning [21].

Study Findings and Procurement Evidence

Pinealon literature provides research context. Procurement review separately requires the label, COA, analytical methods, lot number, and research-use-only statement.

Buy Pinealon for Research: COA Documentation Review

Review what the COA identifies, what it does not prove by itself, and how it connects the supplied material to its lot record.

For Pinealon, a strong COA review should connect the certificate to the product listing and batch. It should also identify whether HPLC, LC-MS, mass spectrometry, or other analytical methods are listed.

What COA Documentation Should Identify

COA documentation should identify the compound, lot number, test date or certificate date, method, purity result, and identity support when available. eCFR labeling provisions for laboratory reagent contexts include purity and quality statements, storage instructions, and lot or control number information [22].

For reference-material documentation, ISO Guide 31 describes certificates and product information sheets as documentation intended to help users assess suitability [23]. That same documentation logic supports peptide COA review.

How Batch-Specific Documentation Supports Traceability

Batch-specific documentation supports traceability by connecting the physical research material to a particular lot. NIST describes reference materials as having certificates that state certified property values, which illustrates why documentation should be tied to a defined material record [24].

Traceability also improves comparability across lab records. A review of metrological traceability describes traceability to recognized reference systems as a key element in assuring comparable measurement results [26].

Why Certificate Dates and Lot Numbers Matter

Certificate dates and lot numbers matter because research documentation should be batch-specific and time-specific. The eCFR identifies lot or control numbers as information that can help determine manufacturing history in relevant laboratory contexts [22].

For Pinealon research procurement, the COA date, lot number, and product label should match. If the records do not align, the listing should be reviewed more carefully.

Analytical Testing for Pinealon Peptide Identity

Analytical testing documents peptide identity and purity. For Pinealon, relevant methods include HPLC, LC-MS, and mass spectrometry.

Here is a numbered lab-test verification sequence for documentation review:

1. Match the compound name, sequence, formula, and lot number across the product listing, label, and COA.
2. Review the batch-specific COA and certificate date.
3. Confirm whether the purity method is listed, such as HPLC.
4. Confirm whether identity support is listed, such as LC-MS or mass spectrometry.
5. Review chromatogram or mass data when available.
6. Check whether the laboratory source or testing attribution is stated.
7. Record storage documentation and batch notes in the laboratory record.

ICH Q2(R2) places identity, purity, impurities, and assay among common analytical measurement objectives, while ICH Q14 addresses science- and risk-based analytical procedure development [18], [20].

How HPLC Supports Peptide Purity Review

HPLC supports peptide purity review by separating peptide components and related impurities under chromatographic conditions. HPLC methods are widely used for peptide analysis and purification, including reversed-phase, ion-exchange, and size-exclusion modes [15].

How LC-MS Supports Identity Verification

LC-MS supports identity verification by pairing liquid chromatography with mass-spectrometry detection. LC-HRMS has been used for qualitative and quantitative characterization of peptide drugs and related impurities in analytical research [17].

For Pinealon peptide identity, LC-MS can help connect observed mass data with the expected compound record. It does not replace the need to match the lot number, COA, product listing, and label.

What Mass Spectrometry Adds to Sequence Confirmation

Mass spectrometry adds mass-based evidence that can support synthetic peptide characterization. Reviews of synthetic peptide mass spectral analysis describe MS as a tool for evaluating peptide detection and characterization limits [16].

For short peptides such as Pinealon, mass data can strengthen identity review when the expected molecular record is known. It should be interpreted with method details and batch documentation.

Supplier Documentation and Research Procurement Review

A procurement review checks whether the supplier clearly states the RUO scope, provides batch-level documentation, and identifies analytical methods consistent with the supplied material.

RUO Labeling and Research Use Consistency

RUO labeling should be consistent across the product page, product label, COA, and supporting documentation. FDA guidance explains RUO labeling for certain research products and emphasizes alignment between labeling and intended research positioning [21].

Literature findings and batch records answer different questions. Confirm that Pinealon’s research-only designation is consistent across the documents.

What Lab Teams Should Verify Before Ordering

• Verify that the compound is labeled for research use only.
• Review the batch-specific certificate of analysis.
• Confirm that purity data are supported by an analytical method.
• Check that the lot number on the COA matches the product documentation.
• Compare compound name, molecular formula, and sequence across documentation [1], [14].
• Assess whether the product page keeps research literature separate from product claims.
• Document storage and handling conditions in a laboratory record.

This checklist supports procurement review without moving into application guidance. It is a documentation checklist, not a product-use guide.

How Storage Documentation Supports Research Workflows

Storage documentation supports research workflows by giving laboratories a record of conditions that protect material integrity within the supplier’s stated framework. ICH Q1A describes stability testing as evidence for how quality varies with time under environmental factors such as temperature, humidity, and light [25].

Laboratory teams should follow supplier documentation and institutional procedures without treating the product page as a handling manual.

Common Misunderstandings About Pinealon Research

• Published literature does not equal product-page claims.
• Preclinical findings should remain model-specific.
• A purity percentage does not prove complete compound identity.
• A COA should be batch-specific.
• Pathway relevance does not equal a product outcome.
• RUO labeling identifies a laboratory research material.

These misunderstandings are common because Pinealon research sits near gene expression, oxidative stress, neuroprotective research models, and preclinical literature.

Next Steps for Research Documentation Review

Review the product-page documentation, COA details, analytical testing references, lot traceability, and RUO labeling before evaluating Pinealon for laboratory research. For research teams comparing peptide suppliers, prioritize transparent documentation, consistent labeling, and batch-level records.

Pure Lab Peptides product information should be read as research-use-only documentation support. Keep the focus on compound identity, research context, COA review, and supplier documentation before selecting any RUO peptide compound.

FAQs

What does research use only mean for Pinealon?

Research use only means Pinealon is intended solely as a laboratory research material.

What should researchers consider before they buy Pinealon for research?

Researchers should consider documentation consistency before they buy Pinealon for research. The product listing, RUO labeling, batch-specific COA, lot number, and analytical testing records should align. For Pinealon, the compound identity should also match Glu-Asp-Arg documentation, including peptide sequence and molecular record where available [1].

Why does a COA matter when evaluating Pinealon?

A COA matters for Pinealon because it provides batch-specific documentation that can connect the listed research material to purity, identity, lot number, and certificate details. A COA should be reviewed alongside the product label and supplier documentation. It supports research procurement review, but it should not be treated as a stand-alone substitute for complete analytical documentation.

How can researchers verify Pinealon purity and identity?

Researchers can verify Pinealon purity and identity by reviewing analytical testing documentation. HPLC can support peptide purity review, while LC-MS and mass spectrometry can support peptide identity confirmation when paired with batch-specific documentation [15], [16]. The strongest review compares the COA, product listing, lot number, and expected Pinealon peptide identity in one documentation record.

How should published literature about Pinealon be interpreted?

Published Pinealon literature provides research context, not evidence of outcomes for a supplied product. Studies may discuss neuronal models, receptor signaling, epigenetics, redox context, kinase pathways, or other model-specific mechanisms; interpret each within its study conditions and limitations.

Researchers Cited in This Guide

The researchers listed below are cited for relevant published work. Their inclusion does not imply that they wrote, reviewed, or endorsed this guide or Pure Lab Peptides products.

Vladimir Khatskelevich Khavinson

Author profile: RUDN Journal Profile

Vladimir Khatskelevich Khavinson’s publications address Pinealon as Glu-Asp-Arg, EDR peptide research, gene-expression models, protein synthesis, and oxidative-stress studies. The selected publications provide background on compound identity and model-specific findings.

Selected publications:

• A Pinealon cell-model study involving oxidative-stress and ERK 1/2 research — Rejuvenation Research, 2011. DOI: 10.1089/rej.2011.1172.
• EDR peptide gene-expression and protein-synthesis review — Molecules, 2021. DOI: 10.3390/molecules26010159.

Natalia Sergeevna Linkova

Author profile: SciProfiles

Natalia Sergeevna Linkova is a coauthor of publications on short peptides and Pinealon, including gene expression, epigenetics, and DNA–peptide interaction models. The selected publications provide background on ultrashort peptides and pathway-level research.

Selected publications:

• Peptide Regulation of Gene Expression: A Systematic Review — Molecules, 2021. DOI: 10.3390/molecules26227053.
• A review relevant to ultrashort peptide epigenetics and gene-expression context — International Journal of Molecular Sciences, 2022. DOI: 10.3390/ijms23084259.

REFERENCES

1. National Center for Biotechnology Information. Glu-Asp-Arg compound record. PubChem. Updated record accessed 2026.
2. Khavinson V, Linkova N, Kozhevnikova E, Trofimova S. EDR peptide gene-expression review. Molecules. 2021. DOI: 10.3390/molecules26010159. PMID: 33396470.
3. Fedoreyeva LI, Kireev II, Khavinson VK, et al. Short peptide nuclear-localization and DNA-interaction study. Biochemistry Moscow. 2011. DOI: 10.1134/S0006297911110022.
4. Silanteva IA, Komolkin AV, Morozova EA, Vorontsov-Velyaminov PN, Kasyanenko NA. Glu-Asp-Arg DNA interaction study. Journal of Physical Chemistry B. 2019. DOI: 10.1021/acs.jpcb.8b10359. PMID: 30762356.
5. Khavinson V, Ribakova Y, Kulebiakin K, Vladychenskaya E, Kozina L, Arutjunyan A, Boldyrev A. Pinealon in oxidative-stress cell-model research. Rejuvenation Research. 2011. DOI: 10.1089/rej.2011.1172. PMID: 21978084.
6. Arutjunyan A, Kozina L, Stvolinskiy S, Bulygina Y, Mashkina A, Khavinson V. Pinealon in prenatal hyperhomocysteinemia model literature. International Journal of Clinical and Experimental Medicine. 2012. PMID: 22567179. PMCID: PMC3342713.
7. Karantysh GV, Fomenko MP, Butenko EV. Pinealon and NMDA receptor subunit gene-expression study. Neurochemical Journal. 2020. DOI: 10.1134/S181971242003006X.
8. Mendzheritskii AM, Karantysh GV, et al. Cortexin and Pinealon hypoxia and hypothermia model literature. PubMed-indexed record. 2015. PMID: 28509493.
9. Khavinson VK, et al. Short peptides and neuronal signaling molecule expression literature. PubMed-indexed record. 2011. PMID: 22803060.
10. Khavinson VK, et al. Peptide regulation of gene expression review. Molecules. 2021. DOI: 10.3390/molecules26227053. PMID: 34834147.
11. Ilina A, et al. Ultrashort peptide neuroepigenetic mechanisms review. International Journal of Molecular Sciences. 2022. DOI: 10.3390/ijms23084259.
12. Khavinson V, Linkova N, Kozhevnikova E, Dyatlova A, Petukhov M. Ultrashort peptide transport review. International Journal of Molecular Sciences. 2022. DOI: 10.3390/ijms23147733. PMID: 35887081.
13. Kraskovskaya N, et al. Short peptides in induced-neuron in vitro models. International Journal of Molecular Sciences. 2024. PMCID: PMC11546785.
14. IUPAC-IUB Joint Commission on Biochemical Nomenclature. Amino acid symbols and peptide nomenclature. IUPAC/IUBMB recommendations.
15. Mant CT, Hodges RS. HPLC analysis and purification of peptides. Methods in Molecular Biology. 2007. PMCID: PMC7119934.
16. Jagannadham MV. Mass spectral analysis of synthetic peptides. Methods and Protocols. 2021. PMCID: PMC7704033.
17. Zeng K, et al. LC-HRMS peptide characterization and related-impurity analysis. Journal of Pharmaceutical and Biomedical Analysis. 2015. PMCID: PMC4406950.
18. International Council for Harmonisation. Q2(R2) Validation of Analytical Procedures. ICH Harmonised Guideline. 2023.
19. U.S. Food and Drug Administration. Q2(R2) Validation of Analytical Procedures. FDA Guidance. 2024.
20. International Council for Harmonisation. Q14 Analytical Procedure Development. ICH Harmonised Guideline. 2023.
21. U.S. Food and Drug Administration. Distribution of products labeled for research use only or investigational use only. FDA Guidance for Industry and FDA Staff. 2013; FDA page current as of 2018.
22. Electronic Code of Federal Regulations. 21 CFR 809.10 labeling for in vitro diagnostic products. eCFR. Accessed 2026.
23. International Organization for Standardization. ISO Guide 31:2015 Reference materials documentation. ISO. 2015.
24. National Institute of Standards and Technology. Reference materials and certificates of analysis. NIST. Accessed 2026.
25. International Council for Harmonisation. Q1A(R2) Stability Testing of New Drug Substances and Products. ICH Harmonised Guideline. 2003.
26. Panteghini M. Traceability, reference systems, and result comparability. Clinical Biochemistry Reviews. 2007. PMCID: PMC1994107.
27. Yilmaz A, Grotewold E. Components and mechanisms of regulation of gene expression. Methods in molecular biology (Clifton, N.J.). 2010. PMID: 20827583.

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Research Disclaimer

This material is supplied strictly for in vitro laboratory research and is not for human or veterinary use. Published studies describe specific experimental materials, models, and methods; they do not establish the safety, efficacy, or suitability of this catalog product for non-research use. Review the original publications and the lot-specific analytical documentation independently.