Important

Research Use Notice

All articles and product information provided on this website are for informational and educational purposes only. The products offered on this website are intended solely for research and laboratory use. These products are not intended for human or animal consumption. They are not medicines or drugs and have not been evaluated or approved by the FDA to diagnose, treat, cure, or prevent any disease or medical condition. Do not administer these products to humans or animals.

Product Documentation

Details, specifications, and documents

Description

IGF-1 DES 2 mg: research material

Buy IGF-DES 2 mg (IGF-1 DES) for laboratory research, supplied as lyophilized powder in one boxed 3 mL vial.

IGF-1 DES is associated with the Des(1-3)-IGF-I reference construct, a shortened form of insulin-like growth factor I. The designation refers to removal of the first three N-terminal residues, Gly-Pro-Glu.

Choose the material and presentation

The N-terminal deletion distinguishes DES(1-3) from native IGF-I. LR3 is another modified construct, not a different package size of the same molecule. The published chondrocyte study describes these different modifications in its experimental context.

For the IGF-DES catalog material, match the exact construct in the supplied records to the method. Binding to an IGF receptor and binding to an IGF-binding protein are separate interactions; a claim about one should not be substituted for the other. Avoid assuming a universal potency multiplier from the analog name.

IGF-1 DES in analytical research

Mongongu and colleagues developed an antibody-based purification method followed by nano-liquid chromatography and high-resolution mass spectrometry for modified IGF-I analytes, including Des(1-3)-IGF-I. They assessed analytical performance in fortified human serum, including specificity, recovery and matrix effects.

The study found oxidized peptide forms in the commercial materials it examined, supporting the inclusion of native and mono-oxidized analytes in its detection approach. That observation belongs to those samples; it is not a finding about this product. The method concerns analytical detection and does not establish biological potency or a clinical effect.

Original study

Product records and batch reports

Review available reports in the product documentation section and match the product name, construct and lot. A mass-spectrometric identity result, a chromatographic purity percentage and a biological activity assay answer different questions.

The labeled 2 mg is the amount in this presentation, not a prepared solution concentration. Use the chemical form and assay requirements in the relevant records when planning analytical work; no stability period or equivalence to another IGF construct is implied.

Additional information

CAS No.

112603-35-7

Purity

≥99%

Applications

Muscle hypertrophy research, tissue-regeneration studies, anabolic signaling investigations

Synthesis

Solid-phase synthesis

Solubility

Soluble in water or 1% acetic acid

Stability & Storage

Stable for up to 24 months at -20°C.

Appearance

White lyophilized powder

Shipping Conditions

Shipped at ambient temperature; once received, store at -20°C

Regulatory/Compliance

Manufactured in a facility that adheres to cGMP guidelines

Safety Information

Refer to provided MSDS

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