PNC-27 30 mg

Buy PNC-27 30 mg for laboratory research, supplied as lyophilized powder in one boxed 3 mL vial.

PNC-27 is a designed peptide combining a p53-derived region with a membrane-active leader. It is studied in cell-membrane and HDM-2 research.

Choose the complete construct

The 2010 PNC-27 study specifies a 32-residue construct containing p53 residues 12-26 plus its membrane-active segment. The number 27 in the product name is not the complete amino-acid count. PNC-28 uses a different p53 segment and should not be treated as the same material.

Before comparing molecular specifications, check the full sequence, terminal chemistry and supplied form against the method you intend to use. A reference peptide’s identity does not replace analytical verification of a purchased batch.

The 30 mg label describes the amount supplied, while 3 mL describes the vial’s capacity. Neither specifies a prepared solution concentration or an experimental exposure level.

HDM-2 at the cell membrane

The original study used membrane-fraction analysis and fluorescence microscopy to examine HDM-2 and PNC-27 in cancer and nonmalignant cell models. The investigators observed PNC-27 and HDM-2 together at cancer-cell membranes, supporting a membrane-associated mechanism.

They also engineered initially nonsusceptible MCF-10-2A cells to express full-length HDM-2 at the membrane. Those cells became susceptible. This result makes the membrane context important; it does not support a blanket statement that every nonmalignant cell is spared.

These experiments concern particular cell systems and controls. They do not establish a treatment outcome or guarantee equivalent selectivity for another cell type or supplied preparation.

Product documents and batch identity

Use Documents to inspect the files available for this product. For any lot-specific report, confirm the product and batch match the material being evaluated. Identity evidence, chromatographic purity and measured content answer separate questions; a percentage alone cannot substitute for the other checks.

Confirm solvent compatibility, storage and stability of prepared material for your assay. General supplier handling statements or results obtained with another construct do not establish those conditions for this vial.